Results 91 to 100 of about 15,257 (261)

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials [PDF]

, 2014
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
Bringela, A., Chadwick, J., Copple, I. M., Cristiano, Maria Lurdes Santos, Donegan, G., Firman, J., Herpers, B., Mercer, A. E., O'Neill, Paul M., Park, B. K., Van De Water, B., Ward, Stephen A., Wong, M. H.   +12 more
core  

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review [PDF]

, 2018
Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of ...
Boas, Ulrik, Enemark, Heidi L., López-Muñoz, Rodrigo, Peña-Espinoza, Miguel, Simonsen, Henrik T., Thamsborg, Stig M., Valente, Angela H., Williams, Andrew R.   +7 more
core   +4 more sources

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Artemisinin

HIMALAYA, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material. The ‘active principle’ was first extracted in 1820 and named quinine.
openaire   +1 more source

Population pharmacokinetics of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria in Western Kenya

British Journal of Clinical Pharmacology, EarlyView.
Aim This study intends to assess the pharmacokinetic properties and treatment response of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria infection in Western Kenya. Methods Seventy‐five women with uncomplicated P.
Elizabeth Juma, Junjie Ding, Martin Ongas, Nelly Koskei, Kevin Onyango, Florence Oloo, Rashid Aman, Gilbert Kokwaro, Joel Tarning, Bernhards Ogutu   +9 more
wiley   +1 more source

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica [PDF]

, 2017
Triclabendazole is the drug of choice against Fasciola hepatica infections in humans and animals. However, parasite resistance against triclabendazole is spreading in the veterinary field, and there are no drugs of comparable activity currently available
Brennan, Gerry, Dong, Yuxiang, Fairweather, Ian, Keiser, Jennifer, Utzinger, Jürg, Vennerstrom, Jonathan L.   +5 more
core  

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Efficacy and Tolerability of Antimalarials and Molecular Resistance Markers of Falciparum Malaria in Jimma Region, Ethiopia [PDF]

, 2011
Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries.
Eshetu, Teferi
core  

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials [PDF]

, 2012
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
AC Beekman, AE Mercer, AE Mercer, Amy E. Mercer, Andreia D. Bringela, B. Kevin Park, Bob van de Water, Bram Herpers, CW Jefford, D Cardi, DA New, DP Williams, F Bousejra-El Garah, Gail Donegan, GL Disbrow, GL Firestone, Ian M. Copple, J Fishwick, J Hou, James Chadwick, James Firman, JC Puigvert, M Desai, M Kaiser, M Longo, M Longo, MA Fugi, Maria L. S. Cristiano, Michael H. L. Wong, NA Brown, NH Hunt, OW Griffith, P Olliaro, PA Stocks, Paul M. O’Neill, PD Brown-Woodman, PM O’Neill, PM O’Neill, RK Haynes, RK Haynes, RK Haynes, RL Clark, S D’Alessandro, S Krishna, S Toovey, SA Charman, Stephen A. Ward, T Efferth, WHO, WHO, X Gao, Y Dong   +51 more
core   +1 more source

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

The FEBS Journal, EarlyView.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source