Results 121 to 130 of about 15,257 (261)

World Antimalarial Resistance Network (WARN) III: Molecular Markers for Drug Resistant Malaria [PDF]

, 2010
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Barnwell, John W, Happi, Christian Tientcha, Joshi, Hema H, Mbacham, Wilfred, Meshnick, Steven R, Mugittu, Kefas, Naidoo, Inbarani, Plowe, Christopher V, Price, Ric N., Roper, Cally, Rosenthal, Philip J, Shafer, Robert W, Sibley, Carol H, Sutherland, Colin J, Zimmerman, Peter B.   +14 more
core   +2 more sources

Artemisinin: current status

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
The compounds derived from the Chinese medicinal plant qinghao (Artemisia annua) are the most rapidly acting of all antimalarial drugs. They are effective when given parenterally, orally or by suppository. No serious adverse effect has yet been reported in humans.
openaire   +2 more sources

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Haemolysis associated with the treatment of malaria with artemisinin derivatives: a systematic review of current evidence

International Journal of Infectious Diseases, 2014
Background: Artemisinin derivatives are the mainstay of antimalarial treatment, both for uncomplicated malaria and for severe disease. Artemisinins are known for their rapid onset of action, good tolerability, and safety.
Khalid Rehman, Felix Lötsch, Peter G. Kremsner, Michael Ramharter   +3 more
doaj   +1 more source

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part II: Model-Based Design of Agitated and Packed Columns for Multistage Extraction and Scrubbing [PDF]

, 2018
A. Schmidt, Maximilian Sixt, Maximilian Johannes Huter, Fabian Mestmäcker, Jochen Strube   +4 more
openalex   +1 more source

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Artemisone effective against murine cerebral malaria

Malaria Journal, 2010
Background Artemisinins are the newest class of drug approved for malaria treatment. Due to their unique mechanism of action, rapid effect on Plasmodium, and high efficacy in vivo, artemisinins have become essential components of malaria treatment ...
Waknine-Grinberg Judith H, Hunt Nicholas, Bentura-Marciano Annael, McQuillan James A, Chan Ho-Wai, Chan Wing-Chi, Barenholz Yechezkel, Haynes Richard K, Golenser Jacob   +8 more
doaj   +1 more source

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance [PDF]

, 2018
Matthew J. Grigg, Timothy William, Kim A. Piera, Giri Shan Rajahram, Jenarun Jelip, Ammar Aziz, Jayaram Menon, Jutta Marfurt, Ric N. Price, Sarah Auburn, Bridget E. Barber, Tsin Wen Yeo, Nicholas M. Anstey   +12 more
openalex   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Pfatp6 molecular profile of Plasmodium falciparum isolates in the western Brazilian Amazon

Malaria Journal, 2012
Background Anti-malarial drug resistance has emerged as one of the biggest challenges confronting the worldwide effort to control malaria. The appearance of chloroquine and multi-drug resistance had devastating effects on therapeutic efficacy of former ...
Brasil Larissa W, Areas André LL, Melo Gisely C, Oliveira Cintia MC, C Alecrim Maria G, G Lacerda Marcus V, O'Brien Connor, Oelemann Walter MR, Zalis Mariano G   +8 more
doaj   +1 more source