Results 11 to 20 of about 17,496 (173)
Postgraduate Medical Journal, 2005 Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
Haynes, RK, Krishna, S, Woodrow, CJ
core +6 more sources
Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum [PDF]
Malaria Journal, 2018 BackgroundThe increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs.
M. Duffey, Cecilia P. Sanchez, M. Lanzer
semanticscholar +3 more sources
Methylene Homologues of Artemisone: An Unexpected Structure–Activity Relationship and a Possible Implication for the Design of C10‐Substituted Artemisinins [PDF]
ChemMedChem, 2016 We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O‐ and N‐glycosides into more stable C‐glycosides that may possess enhanced ...
Yuet Wu +9 more
semanticscholar +3 more sources
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
New England Journal of Medicine, 2023 BACKGROUND Partial resistance of Plasmodium falciparum to the artemisinin component of artemisinin-based combination therapies, the most important malaria drugs, emerged in Southeast Asia and now threatens East Africa. Partial resistance, which manifests
Melissa D. Conrad +16 more
semanticscholar +1 more source
International Journal of Oral Science, 2023 Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis.
Xiaoyue Liang +12 more
semanticscholar +1 more source
Frontiers in Plant Science, 2022 Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual endoperoxide 1, 2, 4-trioxane ring. It is derived from the herbal medicinal plant Artemisia annua and is best known for its use in treatment of malaria.
Karim Farmanpour-Kalalagh +4 more
semanticscholar +1 more source
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics
Acta Pharmaceutica Sinica B, 2021 Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
David Dolivo +2 more
openaire +4 more sources
Antimicrobial Agents and Chemotherapy, 2003 A recent Letter to the Editor (R. K. Haynes, D. Monti, D. Taramelli, N. Basilico, S. Parapini, and P. Olliaro, Letter, Antimicrob. Agents Chemother. 47:1175, 2003) presented cogent evidence that artemisinin and its derivatives do not inhibit hemozoin formation in vitro.
Haynes, Richard K. +5 more
openaire +6 more sources
Antimicrobial Agents and Chemotherapy, 2021 As artemisinin combination therapies (ACTs) are compromised by resistance, we are evaluating triple combination therapies (TACTs) comprising an amino-artemisinin, a redox drug, and a third drug with different mode of action.
D. Watson +5 more
semanticscholar +1 more source
Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]
, 2020 A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia +5 more
core +1 more source