Results 11 to 20 of about 15,257 (261)
Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum [PDF]
Malaria Journal, 2018 Background The increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs.
Maëlle Duffey +2 more
doaj +3 more sources
Artemether resistance
Malaria Journal, 2012 Background Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins. Methods Plasmodium falciparum
Pillai Dylan R +6 more
doaj +2 more sources
Potential applications of artemisinins in ocular diseases [PDF]
International Journal of Ophthalmology, 2019 Artemisinin, also named qinghaosu, is a family of sesquiterpene trioxane lactone originally derived from the sweet wormwood plant (Artemisia annua), which is a traditional Chinese herb that has been universally used as anti-malarial agents for many years.
Bing-Wen Lu, Li-Ke Xie
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 2003 A recent Letter to the Editor (R. K. Haynes, D. Monti, D. Taramelli, N. Basilico, S. Parapini, and P. Olliaro, Letter, Antimicrob. Agents Chemother. 47:1175, 2003) presented cogent evidence that artemisinin and its derivatives do not inhibit hemozoin formation in vitro.
Haynes, Richard K. +5 more
openaire +5 more sources
Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs. [PDF]
PLoS ONE, 2012 Plasmodium falciparum malaria is a major global health problem, causing approximately 780,000 deaths each year. In response to the spreading of P. falciparum drug resistance, WHO recommended in 2001 to use artemisinin derivatives in combination with a ...
Benoit Witkowski +8 more
doaj +1 more source
Artemether treatment improves islet function and metabolic homeostasis in diabetic nonhuman primates
Journal of Diabetes, 2023 Highlights Artemether increased the serum concentration of c‐peptide and decreased the usage of insulin in the diabetic monkey. Artemether downregulated the serum concentration of total cholesterol and low‐density lipoprotein cholesterol in the diabetic ...
Wei Fu, Jiang Hongwei, Jin Li
doaj +1 more source
Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]
, 2020 A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia +5 more
core +1 more source
Biology, Medicine & Natural Product Chemistry, 2021 Artemisinin-based combination (ACT) therapy is the mainstay for malaria treatment. However, Plasmodium parasite with decreased susceptibility to ACT has emerged.
Udeme Owunari Georgewill, Elias Adikwu
doaj +1 more source
Molecules, 2022 As the world desperately searches for ways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A.
Pawan K. Agrawal +2 more
doaj +1 more source
Frontiers in Chemistry, 2020 We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA ...
Ho Ning Wong +12 more
doaj +1 more source