Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]
, 2013 Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth +5 more
core +3 more sources
Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins. [PDF]
, 2016 We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides that may possess enhanced ...
Ariey +79 more
core +1 more source
Frontiers in Pharmacology, 2020 Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging evidence for their excellent antitumor activities.
Cangcang Xu +3 more
doaj +1 more source
Artemisinin resistance in Plasmodium falciparum malaria. [PDF]
, 2009 BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
An, Sen Sam +22 more
core +1 more source
Safety, pharmacokinetics and efficacy of artemisinins in pregnancy
Infectious Disease Reports, 2011 Malaria in pregnancy can lead to serious maternal and fetal morbidity and mortality. Access to the most effective antimalarials in pregnancy is essential.
Veronica Ades
doaj +1 more source
Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]
, 2009 Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE +22 more
core +2 more sources
Molecules, 2021 It has been more than 10 years since we published the Special Issue “Artemisinin (Qinghaosu): commemorative issue in honor of Professor Youyou Tu on the occasion of her 80th anniversary” (Abbreviated as “the Artemisinins Special Issue”) [...]
Yan He, Shu-Kun Lin
doaj +1 more source
Molecules, 2018 According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we ...
Yuet Wu +7 more
doaj +1 more source
Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial [PDF]
, 2016 Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical ...
Barda, Beatrice +5 more
core +3 more sources
Emerging Infectious Diseases, 2017 Antimalarial drug resistance is an evolving global health security threat to malaria control. Early detection of Plasmodium falciparum resistance through therapeutic efficacy studies and associated genetic analyses may facilitate timely implementation of
Eric S. Halsey +24 more
doaj +1 more source