Results 31 to 40 of about 15,257 (261)

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

Frontiers in Chemistry, 2020
Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range of biological activities including anticancer effect.
Yalan Wu, Yalan Wu, Qingping Zeng, Zhiwen Qi, Tao Deng, Fang Liu   +5 more
doaj   +1 more source

Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins. [PDF]

, 2016
We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides that may possess enhanced ...
Ariey, Avery, Batty, Batty, Bhattacharjee, Brewer, Brewer, Campbell, Cho, Conyers, Davis, Delves, Dunay, Efferth, Espinosa, Fieschi, Ford-Moore, Genovese, Genovese, Ghose, Gordi, Gravett, Hall, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Haynes, Hooft van Huijsduijnen, Ilett, Ingelman, Jansen, Jiménez-Barbero, Johann-Liang, Kelter, Kim, Kinoshita, Krishna, Laclau, Li, Lubell, Ma, Ma, Marfurt, Morris, Nivière, Nontprasert, Obaldia, Palfey, Parapini, Phyo, Ramu, Ravishankar, Schmieg, Schmuck, Schmuck, Schmuck, Smith, Teyssot, Tilley, Toovey, Toovey, Toovey, Toovey, Toovey, van Agtmael, Vivas, Waknine-Grinberg, Waknine-Grinberg, Wells, Woodrow, Xu, Zhou   +79 more
core   +1 more source

Safety, pharmacokinetics and efficacy of artemisinins in pregnancy

Infectious Disease Reports, 2011
Malaria in pregnancy can lead to serious maternal and fetal morbidity and mortality. Access to the most effective antimalarials in pregnancy is essential.
Veronica Ades
doaj   +1 more source

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

Molecules, 2018
According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we ...
Yuet Wu, Silvia Parapini, Ian D. Williams, Paola Misiano, Ho Ning Wong, Donatella Taramelli, Nicoletta Basilico, Richard K. Haynes   +7 more
doaj   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
An, Sen Sam, Ariey, Frederic, Chotivanich, Kesinee, Das, Debashish, Day, Nicholas PJ, Dondorp, Arjen M, Hanpithakpong, Warunee, Herdman, Trent, Imwong, Mallika, Lee, Sue J, Lim, Pharath, Lindegardh, Niklas, Lwin, Khin Maung, Nosten, François, Phyo, Aung Phae, Ringwald, Pascal, Silamut, Kamolrat, Singhasivanon, Pratap, Socheat, Duong, Tarning, Joel, White, Nicholas J, Yeung, Shunmay, Yi, Poravuth   +22 more
core   +1 more source

Capacity Development through the US President’s Malaria Initiative–Supported Antimalarial Resistance Monitoring in Africa Network

Emerging Infectious Diseases, 2017
Antimalarial drug resistance is an evolving global health security threat to malaria control. Early detection of Plasmodium falciparum resistance through therapeutic efficacy studies and associated genetic analyses may facilitate timely implementation of
Eric S. Halsey, Meera Venkatesan, Mateusz M. Plucinski, Eldin Talundzic, Naomi W. Lucchi, Zhiyong Zhou, Celine I. Mandara, Hawela Moonga, Busiku Hamainza, Abdoul Habib Beavogui, Simon Kariuki, Aaron M. Samuels, Laura C. Steinhardt, Don P. Mathanga, Julie Gutman, Yves Eric Denon, Aline Uwimana, Ashenafi Assefa, Jimee Hwang, Ya Ping Shi, Pedro Rafael Dimbu, Ousmane Koita, Deus S. Ishengoma, Daouda Ndiaye, Venkatachalam Udhayakumar   +24 more
doaj   +1 more source

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]

, 2009
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE, Alonso, Baard, Barakat, Botros, Botros, Cioli, D. CIOLI, D. ENGELS, G. COLES, Keiser, L. A. TCHUEM TCHUENTÉ, L. PICA-MATTOCCIA, M. J. DOENHOFF, Mwanakasale, N'Goran, P. HAGAN, Pica-Mattoccia, S. BOTROS, Stohler, Utzinger, V. SOUTHGATE, Van Wyk   +22 more
core   +2 more sources

Special Issue “Artemisinin (Qinghaosu): Commemorative Issue in Honor of Professor Youyou Tu on the Occasion of Her 80th Anniversary” in International Molecules Published in 2010

Molecules, 2021
It has been more than 10 years since we published the Special Issue “Artemisinin (Qinghaosu): commemorative issue in honor of Professor Youyou Tu on the occasion of her 80th anniversary” (Abbreviated as “the Artemisinins Special Issue”) [...]
Yan He, Shu-Kun Lin
doaj   +1 more source

Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial [PDF]

, 2016
Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical ...
Barda, Beatrice, Coulibaly, Jean T., Hattendorf, Jan, Huwyler, Jörg, Keiser, Jennifer, Puchkov, Maxim   +5 more
core   +3 more sources

Making artemisinin☆

Phytochemistry, 2008
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
openaire   +3 more sources