Results 41 to 50 of about 15,257 (261)

Discovery and repurposing of artemisinin

Frontiers of Medicine, 2022
Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the "best hope for the treatment of malaria" by World Health Organization.
Shi, Qiaoli, Xia, Fei, Wang, Qixin, Liao, Fulong, Guo, Qiuyan, Xu, Chengchao, Wang, Jigang   +6 more
openaire   +2 more sources

Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. [PDF]

, 2017
BACKGROUND: The Plasmodium falciparum multidrug resistance 1 (PfMDR1), P. falciparum Ca(2+)-ATPase (PfATP6) and Kelch-13 propeller domain (PfK13) loci are molecular markers of parasite susceptibility to anti-malarial drugs.
A Afonso, A Amambua-Ngwa, AB Sidhu, AB Sidhu, AC Uhlemann, AC Uhlemann, AC Uhlemann, AC Uhlemann, AF Cowman, AM Dondorp, AP Phyo, Ayola Akim Adegnika, B Greenwood, B Kwansa-Bentum, B Witkowski, Bernhards R. Ogutu, C Amaratunga, C Amaratunga, C Sisowath, Christian N. Nguetse, CN Nguetse, CN Nguetse, E Legrand, EA Ashley, EA Ashley, F Ariey, F Huang, F Koukouikila-Koussounda, F Nawaz, FL Eyase, G Holmgren, G Zhang, GS Humphreys, H Noedl, IH Cheeseman, IM Hastings, J Chilongola, J Straimer, JA Flegg, K Mugittu, K Na-Bangchang, K Tanabe, KJ Livak, M Malmberg, M Malmberg, M Miao, M Venkatesan, MB Reed, MD Spalding, MI Veiga, ML Ibrahim, MP Kyaw, MT Duraisingh, MT Duraisingh, MT Duraisingh, N Wurtz, NJ White, NO Duah, NW Lucchi, Peter G. Kremsner, PG Kremsner, PI Mayengue, R Jambou, R Jambou, R Tahar, RN Price, RN Price, S Cojean, S Krishna, S Krishna, S Meshnick, S Pulcini, S Ruetz, S Takala-Harrison, S Takala-Harrison, S Tukwasibwe, S Zakeri, Sanjeev Krishna, SG Valderramos, SK Mekonnen, Thirumalaisamy P. Velavan, TP Velavan, Tsiri Agbenyega, TT Thomsen, TT Thomsen, U Eckstein-Ludwig, WHO, WHO, WHO   +88 more
core   +1 more source

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract – possible synergistic and resistance mechanisms [PDF]

Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin.
A Belkaid, A De Donno, A Nemeikaitė-Čėnienė, ABS Sidhu, Alexander P. Gorka, Alexei A. Lapkin, AR Bilia, AV Pandey, B Tepe, B Zhang, BC Elford, CW Jefford, CW Wright, D Cao, E Hsu, E Hsu, EG Yordi, F Van der Kooy, FH Jansen, G Noratto, Gabriele Pradel, Guy C. Barker, H Wagner, H Wagner, H Wagner, HJ Woerdenbag, İ Gülçin, J Golenser, J Mouton, J Suberu, J Wang, J-G Xu, John O. Suberu, K Liu, K Rath, L Cui, L Vivas, L-H Wang, Lauren Jacobs, M Friedman, M Petersen, M Willcox, M Willcox, MC Berenbaum, N Acton, N Erkan, N Klonis, Neil Sullivan, P Miketova, Paul D. Roepe, PG Bray, PJ Weathers, PJ Weina, PK Agrawal, PM De Magalhaes, PM O’Neill, PT Lansbury, QL Fivelman, R Feng, RK Haynes, RK Haynes, RT Eastman, S De Ridder, T Carbonara, TN Bennett, U Eckstein-Ludwig, W Li, XC Ding, Z Bozdech   +68 more
core   +1 more source

Dihydroartemisinin induces apoptosis in human bladder cancer cell lines through reactive oxygen species, mitochondrial membrane potential, and cytochrome C pathway

International Journal of Preventive Medicine, 2017
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiproliferative effect. However, such effects of DHA have not yet been revealed for bladder cancer cells. Methods: We used as bladder cancer cell lines to examine
Farhad Poupel, Mahmoud Aghaei, Ahmad Movahedian, Seyyed Mehdi Jafari, Mohammad Keyvanloo Shahrestanaki   +4 more
doaj   +1 more source

The Genetic Wiring of Plant Trichomes: From Initiation to Fate Specification

Advanced Science, EarlyView.
Plant trichomes are not just simple hairs but metabolic powerhouses shaped by complex genetic programs. While the MYB‐bHLH‐WD40 module is well studied in Arabidopsis, recent findings reveal that HD‐Zip IV transcription factors drive multicellular and glandular trichome development through dose‐dependent mechanisms.
Meng Li, Yuanbo Huang, Yadi Du, Shuang Wu   +3 more
wiley   +1 more source

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. [PDF]

PLoS ONE, 2010
The biological mode of action of artemisinin, a potent antimalarial, has long been controversial. Previously we established a yeast model addressing its mechanism of action and found mitochondria the key in executing artemisinin's action. Here we present
Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Yicheng Long, Ying Li, Bing Zhou   +7 more
doaj   +1 more source

Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation

International Journal for Parasitology: Drugs and Drug Resistance, 2023
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the peroxide
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill   +6 more
doaj   +1 more source

Genome‐scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid

Advanced Science, EarlyView.
Genome‐scale metabolic modeling is preceded to the engineered E. coli cell factory for the de novo biosynthesis of biopesticide chrysanthemic acid. The debranching strategy redirects metabolic flux, enhancing precursor and target compound production.
Jiangpeng Yu, Kelin Cheng, Shenyang Qu, Jie Wang, Xun Wang, Cheng Zhao, Wei Li   +6 more
wiley   +1 more source

Growth inhibition and anticancer activity of phenoxyartemisinin derivatives in various cancer cell lines [PDF]

Journal of Medicine and Life Science
Cancer remains a significant global health challenge, underscoring the need for novel antineoplastic agents with improved efficacy and reduced toxicity.
Sangtae Oh, Seokjoon Lee, Woon-seob Shin, Nam Hyun Kim   +3 more
doaj   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source