Results 41 to 50 of about 8,416 (212)

Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. [PDF]

, 2017
BACKGROUND: The Plasmodium falciparum multidrug resistance 1 (PfMDR1), P. falciparum Ca(2+)-ATPase (PfATP6) and Kelch-13 propeller domain (PfK13) loci are molecular markers of parasite susceptibility to anti-malarial drugs.
A Afonso, A Amambua-Ngwa, AB Sidhu, AB Sidhu, AC Uhlemann, AC Uhlemann, AC Uhlemann, AC Uhlemann, AF Cowman, AM Dondorp, AP Phyo, Ayola Akim Adegnika, B Greenwood, B Kwansa-Bentum, B Witkowski, Bernhards R. Ogutu, C Amaratunga, C Amaratunga, C Sisowath, Christian N. Nguetse, CN Nguetse, CN Nguetse, E Legrand, EA Ashley, EA Ashley, F Ariey, F Huang, F Koukouikila-Koussounda, F Nawaz, FL Eyase, G Holmgren, G Zhang, GS Humphreys, H Noedl, IH Cheeseman, IM Hastings, J Chilongola, J Straimer, JA Flegg, K Mugittu, K Na-Bangchang, K Tanabe, KJ Livak, M Malmberg, M Malmberg, M Miao, M Venkatesan, MB Reed, MD Spalding, MI Veiga, ML Ibrahim, MP Kyaw, MT Duraisingh, MT Duraisingh, MT Duraisingh, N Wurtz, NJ White, NO Duah, NW Lucchi, Peter G. Kremsner, PG Kremsner, PI Mayengue, R Jambou, R Jambou, R Tahar, RN Price, RN Price, S Cojean, S Krishna, S Krishna, S Meshnick, S Pulcini, S Ruetz, S Takala-Harrison, S Takala-Harrison, S Tukwasibwe, S Zakeri, Sanjeev Krishna, SG Valderramos, SK Mekonnen, Thirumalaisamy P. Velavan, TP Velavan, Tsiri Agbenyega, TT Thomsen, TT Thomsen, U Eckstein-Ludwig, WHO, WHO, WHO   +88 more
core   +1 more source

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Acta Pharmaceutica Sinica B, 2021
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
David Dolivo, Pamela Weathers, Tanja Dominko   +2 more
openaire   +3 more sources

Making artemisinin☆

Phytochemistry, 2008
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
openaire   +3 more sources

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract – possible synergistic and resistance mechanisms [PDF]

Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin.
A Belkaid, A De Donno, A Nemeikaitė-Čėnienė, ABS Sidhu, Alexander P. Gorka, Alexei A. Lapkin, AR Bilia, AV Pandey, B Tepe, B Zhang, BC Elford, CW Jefford, CW Wright, D Cao, E Hsu, E Hsu, EG Yordi, F Van der Kooy, FH Jansen, G Noratto, Gabriele Pradel, Guy C. Barker, H Wagner, H Wagner, H Wagner, HJ Woerdenbag, İ Gülçin, J Golenser, J Mouton, J Suberu, J Wang, J-G Xu, John O. Suberu, K Liu, K Rath, L Cui, L Vivas, L-H Wang, Lauren Jacobs, M Friedman, M Petersen, M Willcox, M Willcox, MC Berenbaum, N Acton, N Erkan, N Klonis, Neil Sullivan, P Miketova, Paul D. Roepe, PG Bray, PJ Weathers, PJ Weina, PK Agrawal, PM De Magalhaes, PM O’Neill, PT Lansbury, QL Fivelman, R Feng, RK Haynes, RK Haynes, RT Eastman, S De Ridder, T Carbonara, TN Bennett, U Eckstein-Ludwig, W Li, XC Ding, Z Bozdech   +68 more
core   +1 more source

Dihydroartemisinin induces apoptosis in human bladder cancer cell lines through reactive oxygen species, mitochondrial membrane potential, and cytochrome C pathway

International Journal of Preventive Medicine, 2017
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiproliferative effect. However, such effects of DHA have not yet been revealed for bladder cancer cells. Methods: We used as bladder cancer cell lines to examine
Farhad Poupel, Mahmoud Aghaei, Ahmad Movahedian, Seyyed Mehdi Jafari, Mohammad Keyvanloo Shahrestanaki   +4 more
doaj   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. [PDF]

PLoS ONE, 2010
The biological mode of action of artemisinin, a potent antimalarial, has long been controversial. Previously we established a yeast model addressing its mechanism of action and found mitochondria the key in executing artemisinin's action. Here we present
Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Yicheng Long, Ying Li, Bing Zhou   +7 more
doaj   +1 more source

Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation

International Journal for Parasitology: Drugs and Drug Resistance, 2023
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the peroxide
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill   +6 more
doaj   +1 more source

Quantifying the pharmacology of antimalarial drug combination therapy. [PDF]

, 2016
Most current antimalarial drugs are combinations of an artemisinin plus a 'partner' drug from another class, and are known as artemisinin-based combination therapies (ACTs). They are the frontline drugs in treating human malaria infections.
Hodel, Eva Maria
core   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source