Results 71 to 80 of about 15,257 (261)
British Journal of Clinical Pharmacology, EarlyView.In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully +3 more
wiley +1 more source
Neuroauditory Toxicity of Artemisinin Combination Therapies—Have Safety Concerns Been Addressed? [PDF]
, 2014 Although artemisinin-based combination therapies (ACTs) are widely viewed as safe drugs with a wide therapeutic dose range, concerns about neuroauditory safety of artemisinins arose during their development.
Gonzalez, Carmen +6 more
core +3 more sources
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley +1 more source
Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica [PDF]
, 2017 Objectives The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats infected with hepatic and biliary stages of Fasciola ...
Decosterd, Laurent +5 more
core
How robust are malaria parasite clearance rates as indicators of drug effectiveness and resistance? [PDF]
, 2015 Artemisinin combination therapies (ACTs) are currently the first line drugs for treating uncomplicated falciparum malaria, the most deadly of the human malarias. Malaria parasite clearance rates estimated from patients' blood following ACT treatment have
Hodel, Eva Maria
core +1 more source
Malaria: an update on treatment of adults in non-endemic countries. [PDF]
, 2006 Every year people die from malaria in Britain and other industrialised countries. Most of these deaths are avoidable: they occur because a patient or doctor has underestimated the severity of the disease or has not considered the diagnosis early enough ...
Lalloo, David +2 more
core +2 more sources
ChemMedChem, EarlyView.Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco +11 more
wiley +1 more source
Artemisinin anti-malarial drugs in China
Acta Pharmaceutica Sinica B, 2016 Discovered by Youyou Tu, one of the 2015 Nobel Prize winners in Physiology or Medicine, together with many other Chinese scientists, artemisinin, artemether and artesunate, as well as other artemisinins, have brought the global anti-malarial treatment to
Zongru Guo
doaj +1 more source
Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians [PDF]
, 2021 Almahamoudou Mahamar +12 more
openalex +1 more source
Neurotoxicity of Artemisinin Derivatives [PDF]
Clinical Infectious Diseases, 2006 tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng +2 more
openaire +3 more sources