Results 71 to 80 of about 17,496 (173)

Addressing the challenge of neonatal mortality.

, 2013
Reducing neonatal mortality remains a challenge with an estimated 3.0 million neonatal deaths in 2011, three-quarters of these in sub-Saharan Africa and Southern Asia.
Blencowe, H, Cousens, S
core   +1 more source

Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Animal Research and One Health, EarlyView.
Therapeutic effect of natural products on chicken coccidiosis. Abstract The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment.
Pan Chen, Kaili Liu, Taojing Yue, Yanan Lu, Senyang Li, Fuchun Jian, Shucheng Huang   +6 more
wiley   +1 more source

Synergistic anti-malarial action of cryptolepine and artemisinins

Malaria Journal, 2016
Cryptolepine (CPE) is the major indoloquinoline isolated from the popular West African anti-malarial plant, Cryptolepis sanguinolenta. CPE possesses various pharmacological activities with potent anti-malarial activity against both chloroquine (CQ ...
A. D. Forkuo, C. Ansah, Kwesi M. Boadu, J. N. Boampong, E. Ameyaw, B. Gyan, A. T. Arku, M. Ofori   +7 more
semanticscholar   +1 more source

Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica [PDF]

, 2017
Objectives The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats infected with hepatic and biliary stages of Fasciola ...
Decosterd, Laurent, Gruyer, Marie-Stella, Keiser, Jennifer, Mercier, Thomas, Perrottet, Nancy, Zanolari, Boris   +5 more
core  

Total synthesis of (+) artemisinin

Arkivoc, 2003
(+) Artemisinin is a sesquiterpene endoperoxide lactone with an unprecedented structure is a natural medicine for the treatment of malaria in particular drug against drug resistant malaria and cerebral malaria. The total synthesis of this novel sesquiterpene is described using an intermolecular radical reaction on important intermediate iodolactone ...
G. Sabitha, Jhillu S. Yadav, R. Satheesh Babu   +2 more
openaire   +4 more sources

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Phytochemicals in Cancer Therapy: A Structured Review of Mechanisms, Challenges, and Progress in Personalized Treatment

Chemistry &Biodiversity, EarlyView.
ABSTRACT Cancer is a major global health concern. Therefore, new treatment options are needed. The phytochemicals have different chemical structures. It also exhibits several other biological activities. Therefore, these compounds are promising anticancer agents. This review aims to identify and assess new candidates for anticancer therapy. Researchers
Alaa A. A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Esam Qnais, Omar Gammoh, Abdelrahim Alqudah, Vijay Mishra, Yachana Mishra, Mohammad Ahmed Khan, Suhel Parvez, Mohamed El‐Tanani, Taher Hatahet   +11 more
wiley   +1 more source

Transmembrane solute transport in the apicomplexan parasite Plasmodium [PDF]

, 2017
Apicomplexa are a large group of eukaryotic, single-celled parasites, with complex life cycles that occur within a wide range of different microenvironments.
Augagneur, Bakouh, Billker, Blackman, Boisson, Bouyer, Bray, Brochet, Bushell, Cardi, Chen, Counihan, Cunningham, Cunningham, Deng, Eckstein-Ludwig, Ellekvist, Ellekvist, Flannery, Gamo, Garcia, Goldgof, Golldack, Guiguemde, Guttery, Hapuarachchi, Holm-Bertelsen, Ismail, Ito, Jiménez-Díaz, Joet, Juge, Kenthirapalan, Kirk, Kirk, Koyama, Kraft, Krishna, Krishna, Labarbuta, Lehane, Lewis, Lim, Lingelbach, Liu, Lourido, Marchetti, Martin, Martin, Martin, Meireles, Meireles, Melchionda, Moreno, Nagamune, Newby, Nishizawa, Ortiz, Pegoraro, Plouffe, Prole, Prudêncio, Pulcini, Pulcini, Qiu, Rajendran, Rotmann, Rottmann, Ruiz, Sahu, Salcedo-Sora, Sayers, Scholtyseck, Sherling, Sidik, Sigel, Slavic, Slavic, Slavic, Spillman, Staines, Staines, Staines, Staines, Teng, Vaidya, Voss, Waight, Waller, Waller, Wang, White, Woodrow, Wright, Wu   +94 more
core   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes [PDF]

, 2017
Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results.
Avery, Mitchell A., Doerig, Christian, Halbert, Jean, Haynes, Richard K., Krishna, Sanjeev, Pittman, Jon K., Pulcini, Serena, Shah, Falgun, Slavic, Ksenija, Staines, Henry M., Tewari, Rita   +10 more
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