Results 71 to 80 of about 8,416 (212)
British Journal of Clinical Pharmacology, EarlyView.Aim This study intends to assess the pharmacokinetic properties and treatment response of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria infection in Western Kenya. Methods Seventy‐five women with uncomplicated P.
Elizabeth Juma +9 more
wiley +1 more source
Artemisinin resistance--modelling the potential human and economic costs. [PDF]
, 2014 BACKGROUND: Artemisinin combination therapy is recommended as first-line treatment for falciparum malaria across the endemic world and is increasingly relied upon for treating vivax malaria where chloroquine is failing.
Ashley, Elizabeth +8 more
core +1 more source
The FEBS Journal, EarlyView.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica [PDF]
, 2017 Objectives The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats infected with hepatic and biliary stages of Fasciola ...
Decosterd, Laurent +5 more
core
How robust are malaria parasite clearance rates as indicators of drug effectiveness and resistance? [PDF]
, 2015 Artemisinin combination therapies (ACTs) are currently the first line drugs for treating uncomplicated falciparum malaria, the most deadly of the human malarias. Malaria parasite clearance rates estimated from patients' blood following ACT treatment have
Hodel, Eva Maria
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Tanshinones, the major bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used to treat cardiovascular and cerebrovascular diseases. While jasmonates (JAs) are known to modulate tanshinones accumulation, the molecular link between JA signalling and tanshinone biosynthesis remains unclear.
Renjun Qu +9 more
wiley +1 more source
Artemisinin anti-malarial drugs in China
Acta Pharmaceutica Sinica B, 2016 Discovered by Youyou Tu, one of the 2015 Nobel Prize winners in Physiology or Medicine, together with many other Chinese scientists, artemisinin, artemether and artesunate, as well as other artemisinins, have brought the global anti-malarial treatment to
Zongru Guo
doaj +1 more source
Neuroauditory Toxicity of Artemisinin Combination Therapies—Have Safety Concerns Been Addressed? [PDF]
, 2014 Although artemisinin-based combination therapies (ACTs) are widely viewed as safe drugs with a wide therapeutic dose range, concerns about neuroauditory safety of artemisinins arose during their development.
Gonzalez, Carmen +6 more
core +3 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Plant glandular trichomes (GTs) are characterised by their ability to synthesise and store abundant secondary metabolites of significant biological importance. The medicinal plant Artemisia argyi exhibits a dense covering of GTs, yet the precise metabolic compositions and the developmental molecular dynamics of A.
Shuting Dong +6 more
wiley +1 more source
Parasite, 2018 The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin derivative with a partner drug, in the treatment of uncomplicated malaria has largely been responsible for the significant reduction in malaria-related mortality in ...
Ouji Manel +3 more
doaj +1 more source