Results 141 to 150 of about 2,051,960 (424)
Advanced Science, EarlyView.Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang +17 more
wiley +1 more source
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients
eLife, 2020 The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and ...
Gian Paolo Rossi +2 more
doaj +1 more source
Hemodynamic assessment of pulmonary hypertension in mice: a model based analysis of the disease mechanism [PDF]
arXiv, 2017 This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the main pulmonary artery for 7 control mice with normal pulmonary function and 5 hypertensive mice with hypoxia induced ...
arxiv
Arterial Hypertension of Patients who Visited “Xh. Kongoli” Hospital in Elbasan During a Period of 2011 - 2014 [PDF]
, 2015 Background: Hypertension remains one of the most important preventable contributors to disease and death. Abundant evidence from randomized controlled trials has shown the benefit of antihypertensive drug treatment in reducing important health outcomes ...
Baushi, Kaçe
core +2 more sources
Advanced Science, EarlyView.In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao +19 more
wiley +1 more source
Parameter inference in a computational model of hemodynamics in pulmonary hypertension [PDF]
arXiv, 2021 Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) $>$ 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary arterial compliance. There are few measurable biomarkers of PH progression, but a conclusive diagnosis of the disease requires invasive right heart catheterization (RHC ...
arxiv
Blood pressure control and antihypertensive treatment in Swiss general practice: a cross-sectional study using routine data [PDF]
AIMS OF THE STUDY: Arterial hypertension is a major global health risk. Global surveys indicate that only half of patients with arterial hypertension receive pharmacotherapy, and only a quarter achieve the primary blood pressure target recommended by ...
Brenner, Roman +6 more
core +1 more source
Pulmonary arterial hypertension in interferonophaties: a case report and a review of the literature [PDF]
, 2019 Background: Pulmonary arterial hypertension consists in an increase of mean pulmonary arterial pressure (PAPm 65 25 mmHg), and may lead to right ventricular failure.
Bobbo, M. +7 more
core +1 more source
Vessel‐On‐A‐Chip Coupled Proteomics Reveal Pressure‐Overload‐Induced Vascular Remodeling
Advanced Science, EarlyView.A vessel‐on‐a‐chip system is developed to replicate both physiological and pathological vessel cyclic stretches. Proteomic analysis reveals pressure‐overload‐induced vascular remodeling, including cellular response to mechanical cues, cellular oxidative stresses, ER stress, and ceramide biosynthesis activation in the vessel‐on‐a‐chip system, well ...
Yanjun Liu +11 more
wiley +1 more source
Sensitivity analysis and uncertainty quantification of 1D models of the pulmonary circulation [PDF]
, 2018 This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a control and hypoxia induced hypertensive mouse. We use local and global sensitivity and correlation analysis to determine parameters that can be inferred from the model and ...
arxiv +1 more source