Results 181 to 190 of about 672,953 (296)

Long‐term immunosuppression of rabbits through oral tacrolimus administration

Animal Models and Experimental Medicine, EarlyView.
Oral gavage of rabbits with 1.5 mg/kg/d of tacrolimus allows for an efficient long‐term (1 year) immunosuppression with minimal side effects and no loss of animals. lmmunosuppressed rabbits are a convenient animal model to investigate the long‐term efficacy of human allografts in vivo.
Alexane Thibodeau, Todd Galbraith, Oumayma Hayouni, Hélène T. Khuong, François Berthod   +4 more
wiley   +1 more source

An easily overlooked cause of pulmonary arterial hypertension-thiamine deficiency. [PDF]

Front Nutr
Zhao Q, Li M, Chen L, Qiu F.
europepmc   +1 more source

SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

Animal Models and Experimental Medicine, EarlyView.
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling, Xilan Dong, Liyan Mao, Chengjun Huang, Linjing Cong, Haizeng Zhang, Jun Cai, Zhenzhen Chen   +7 more
wiley   +1 more source

The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases [PDF]

, 2013
Abdala, Ana P, Burchell, Amy, Engleman, Zoar J, Fudim, Marat, Gourine, Alexander V, Hart, Emma C J, Lobo, Mel, Marina, Nepthali, McBryde, Fiona D, Nightingale, Angus, Patel, Nik, Paton, Julian F R, Ratcliffe, Laura E K, Sobotka, Paul A   +13 more
core   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

Letter to editor on “Thirty‐six‐month results of laparoscopic‐based renal denervation plus unilateral laparoscopic adrenalectomy for the treatment of patients with resistant hypertension caused by unilateral aldosterone‐producing Adenoma”

The Journal of Clinical Hypertension, 2022
Donatella Schiavone, Maurizio Iacobone, Gian Paolo Rossi   +2 more
doaj   +1 more source

Cardiac and arterial hypertrophy and atherosclerosis in hypertension. [PDF]

, 1994
Richard B. Devereux, Mary J. Roman, Antonello Ganau, Giovanni de Simone, Peter M. Okin, Paul Kligfield   +5 more
openalex   +1 more source

Gut Microbiome in Pulmonary Arterial Hypertension-An Emerging Frontier. [PDF]

Infect Dis Rep
Prisco SZ, Oliveira SD, Weir EK, Thenappan T, Al Ghouleh I.   +4 more
europepmc   +1 more source

Changes in hemodynamics of pulmonary artery using Flowire in a canine model of acute pulmonary thromboembolism

Animal Models and Experimental Medicine, EarlyView.
This study investigated changes in pulmonary artery hemodynamics using a Flowire catheter and evaluated the accuracy of Doppler echocardiography in dogs with acute pulmonary thromboembolism (PTE). Ten healthy beagles were anesthetized, and acute pulmonary hypertension (PH) was induced by injecting 300‐μm dextran microspheres.
Tomohiko Yoshida, Katsuhiro Matsuura, Akiko Uemura, Ryou Tanaka   +3 more
wiley   +1 more source

HNRNPA2B1: a novel target in pulmonary arterial hypertension. [PDF]

Front Cardiovasc Med
Wei Y, Wu D, Deng N, Xu F, Luo S, Fan X, Guo H, Chen J, Li W, Si X.   +9 more
europepmc   +1 more source