Results 61 to 70 of about 5,421 (240)

Construction and reliability and validity of the Chinese revised vascular quality of life questionnaire

陆军军医大学学报
Objective To translate and optimize the vascular quality of life questionnaire (VascuQOL) into Chinese, and to obtain a VascuQOL version which is adapted to Chinese culture and language.
LU Sha, LIU Liping, XIANG Bo
doaj   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, Volume 24, Issue 8, August 2025.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

The role of miR‐4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

Malignancy Spectrum, Volume 2, Issue 2, Page 59-73, June 2025.
As a pivotal microRNA (miRNA), miR‐4284 exhibits noteworthy aberrant expression levels across various cancers and diseases, exerting a crucial role in modulating cancer progression and prognosis. Additionally, the article reviews the potential correlations between miR‐4284 and various contemporary treatment modalities, including but not limited to the ...
Chenhao Liang, Yaojie Feng, Yuhua Zhang, Zehua Wang, Xinming Su, Shiwei Duan   +5 more
wiley   +1 more source

Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. [PDF]

PLoS ONE, 2012
Smoking is a major public health problem, but the genetic factors associated with smoking behaviors are not fully elucidated. Here, we have conducted an integrated genome-wide association study to identify common copy number polymorphisms (CNPs) and ...
Natsuhiko Kumasaka, Masayuki Aoki, Yukinori Okada, Atsushi Takahashi, Kouichi Ozaki, Taisei Mushiroda, Tomomitsu Hirota, Mayumi Tamari, Toshihiro Tanaka, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo   +11 more
doaj   +1 more source

Japan's Conditional/Time‐Limited Early Approval System in Regenerative Medicine: A Case Study of Rise and Falls of Autologous Skeletal Myoblast Sheets

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1171-1174, May 2025.
Japan's conditional/time‐limited early approval program, initiated in 2014, aimed to advance regenerative medicine by expediting market access. However, the withdrawal of autologous skeletal myoblast sheets (Heartsheet) due to ineffectiveness raises concerns about the balance between rapid approval and scientific integrity.
Hayase Hakariya, Akihiko Ozaki, Yudai Kaneda, Tetsuya Tanimoto   +3 more
wiley   +1 more source

日本でのJALS-ECC研究によるリスク予測を適用した心血管イベントの一次予防におけるプラバスタチンの経済的評価 [PDF]

, 2014
Yoshie Onishi, Shiro Hinotsu, Yoko M. Nakao, Hisashi Urushihara, Koji Kawakami, Economic Evaluation of Pravastatin for Primary Prevention of Coronary Artery Disease Based on Risk Prediction from JALS-ECC in Japan, Value in Health Regional Issues, Volume ...
Onishi, Yoshie
core   +1 more source

Analysing referral patterns from a primary dermatological clinic to other medical institutions for further care: A survey on patients with certain skin diseases in Japan

JEADV Clinical Practice, Volume 4, Issue 1, Page 181-187, March 2025.
Abstract Background Various skin diseases exist; some require specialist treatment. Consequently, patients with these conditions are often referred from primary dermatological clinics to other medical institutions for further secondary or tertiary care.
Daisuke Ueo, Takashi Sakai, Erika Ochiai, Jun Sese, Yutaka Hatano   +4 more
wiley   +1 more source

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Exploration, Volume 5, Issue 1, February 2025.
Within this review, an in‐depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune‐mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs ...
Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun   +10 more
wiley   +1 more source

Recent advances in biomarkers for senescence: Bridging basic research to clinic

Geriatrics &Gerontology International, Volume 25, Issue 2, Page 139-147, February 2025.
Research on cellular‐level aging has suggested several biomarkers. These factors are responsible for organ senescence; however, the current data do not necessarily support that these cellular markers can be biomarkers for organ or systemic aging. Further research focusing on the translation of cell biology to systemic biology is required.
Takeshi Fukumoto, Tatsuo Shimosawa, Mitsutaka Yakabe, Shota Yoshida, Yohko Yoshida   +4 more
wiley   +1 more source

The role of platelet microvesicles in intercellular communication. [PDF]

, 2016
In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core   +2 more sources