Results 61 to 70 of about 39,537 (208)

Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. [PDF]

PLoS ONE, 2012
Smoking is a major public health problem, but the genetic factors associated with smoking behaviors are not fully elucidated. Here, we have conducted an integrated genome-wide association study to identify common copy number polymorphisms (CNPs) and ...
Natsuhiko Kumasaka, Masayuki Aoki, Yukinori Okada, Atsushi Takahashi, Kouichi Ozaki, Taisei Mushiroda, Tomomitsu Hirota, Mayumi Tamari, Toshihiro Tanaka, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo   +11 more
doaj   +1 more source

Association of red blood cell distribution width/albumin ratio with renal prognosis among patients with type 2 diabetes mellitus: A retrospective cohort study

Journal of Diabetes Investigation, EarlyView.
Red cell distribution width (RDW)/serum albumin ratio (RAR) is a novel and simple inflammatory marker and has emerged as a reliable prognostic marker in various diseases. Our study reveals that a high RAR is a practical and easily obtainable predictive tool for assessing renal risk in patients with T2DM, thereby offering a tangible benefit to ...
Hiroshi Kimura, Kenichi Tanaka, Hirotaka Saito, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama   +7 more
wiley   +1 more source

The role of miR‐4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

Malignancy Spectrum, Volume 2, Issue 2, Page 59-73, June 2025.
As a pivotal microRNA (miRNA), miR‐4284 exhibits noteworthy aberrant expression levels across various cancers and diseases, exerting a crucial role in modulating cancer progression and prognosis. Additionally, the article reviews the potential correlations between miR‐4284 and various contemporary treatment modalities, including but not limited to the ...
Chenhao Liang, Yaojie Feng, Yuhua Zhang, Zehua Wang, Xinming Su, Shiwei Duan   +5 more
wiley   +1 more source

Japan's Conditional/Time‐Limited Early Approval System in Regenerative Medicine: A Case Study of Rise and Falls of Autologous Skeletal Myoblast Sheets

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1171-1174, May 2025.
Japan's conditional/time‐limited early approval program, initiated in 2014, aimed to advance regenerative medicine by expediting market access. However, the withdrawal of autologous skeletal myoblast sheets (Heartsheet) due to ineffectiveness raises concerns about the balance between rapid approval and scientific integrity.
Hayase Hakariya, Akihiko Ozaki, Yudai Kaneda, Tetsuya Tanimoto   +3 more
wiley   +1 more source

Construction and reliability and validity of the Chinese revised vascular quality of life questionnaire

陆军军医大学学报
Objective To translate and optimize the vascular quality of life questionnaire (VascuQOL) into Chinese, and to obtain a VascuQOL version which is adapted to Chinese culture and language.
LU Sha, LIU Liping, XIANG Bo
doaj   +1 more source

The Long Non-coding RNA AC148477.2 Is a Novel Therapeutic Target Associated With Vascular Smooth Muscle Cells Proliferation of Femoral Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Arteriosclerosis obliterans (ASO) is a limb manifestation of large vessel atherosclerosis. Phenotype switching of vascular smooth muscle cells (VSMCs) occurs in the course of the pathological process.
Kangjie Wang, Kangjie Wang, Yanchen Ye, Yanchen Ye, Lin Huang, Lin Huang, Ridong Wu, Ridong Wu, Rongzhou He, Rongzhou He, Chen Yao, Chen Yao, Shenming Wang, Shenming Wang   +13 more
doaj   +1 more source

Analysing referral patterns from a primary dermatological clinic to other medical institutions for further care: A survey on patients with certain skin diseases in Japan

JEADV Clinical Practice, Volume 4, Issue 1, Page 181-187, March 2025.
Abstract Background Various skin diseases exist; some require specialist treatment. Consequently, patients with these conditions are often referred from primary dermatological clinics to other medical institutions for further secondary or tertiary care.
Daisuke Ueo, Takashi Sakai, Erika Ochiai, Jun Sese, Yutaka Hatano   +4 more
wiley   +1 more source

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Exploration, Volume 5, Issue 1, February 2025.
Within this review, an in‐depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune‐mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs ...
Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun   +10 more
wiley   +1 more source

WAYS OF IMPROVEMENT OF LOOP ENDARTERECTOMY RESULTS FROM ILIAC-FEMORAL SEGMENT

Вестник хирургии имени И.И. Грекова, 2015
The article presents an analysis of treatment results of 91 patients with iliac-femoral segment artery occlusion at the period from 2008 to 2014. Patients were divided into 2 groups: main group (n=30) consisted of patients who undergoing a half-closed ...
A. S. Ivanov, D. N. Maistrenko, M. I. Generalov, F. K. Zherebtsov, A. N. Oleshchuk, D. A. Granov, A. V. Gusinskiy, I. V. Mikhailov   +7 more
doaj   +1 more source

Non‐coding RNAs to treat vascular smooth muscle cell dysfunction

British Journal of Pharmacology, Volume 182, Issue 2, Page 246-280, January 2025.
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non‐coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function.
Simon D. Brown, Eftychia Klimi, Wilfried A. M. Bakker, Abdelaziz Beqqali, Andrew H. Baker   +4 more
wiley   +1 more source