Results 71 to 80 of about 8,646 (202)
Frontiers in MedicineBackgroundGouty arthritis (GA) is a crystal-related joint disease caused by the deposition of monosodium urate (MSU) crystals, directly associated with hyperuricemia resulting from purine metabolism disorder and/or reduced uric acid excretion.
Lishi Yu +4 more
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The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases
Genetic Epidemiology, Volume 50, Issue 6, September 2026.ABSTRACT Mendelian randomization (MR) is a human genetics method for inferring causal relationships between risk factors and diseases. A common focus of MR studies has been on the causal inference of a single risk factor on a single disease. This has led to the successful discovery of numerous causal risk factors for disease.
Carla Márquez‐Luna +4 more
wiley +1 more source
ETHORICOXIB IN THE TREATMENT OF RHEUMATIC DISEASES
Современная ревматология, 2010 Ethoricoxib is a new-generation selective COX-2 inhibitor. It has been recently licensed in Russia for the treatment of osteoarthrosis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS), and acute gouty arthritis.
Yu A Olyunin, Yu A Olyunin
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Journal of Foot and Ankle Research, Volume 19, Issue 3, September 2026.ABSTRACT Introduction First metatarsophalangeal (MTP) joint osteoarthritis (OA) is a common and disabling condition that causes substantial pain and impairs quality of life. Cushioned insoles have the potential to lower plantar pressures beneath the hallux and possibly reduce pain, but their clinical effectiveness has not been investigated.
Kade L. Paterson +6 more
wiley +1 more source
[Nimesil treatment of gouty arthritis].
Terapevticheskii arkhiv, 2003 To evaluate efficacy and safety of nimesil, a selective inhibitor of cyclooxigenase-2, in gouty arthritis (GA).Nimesil was given to 20 male patients with GA (mean age 53.8 years, mean duration of the disease 8.1 years) in a dose 100 mg twice a day for 14 or 21 days depending on positive clinical changes (13 and 6 patients, respectively).
V G Barskova, I A Yakunina, V A Nasonova
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Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.ABSTRACT Background A 34‐year‐old man presented to our primary care clinic with persistent pain and swelling of the right first metatarsophalangeal joint lasting 3 months. A previous clinic had suspected gout based on hyperuricemia, but urate‐lowering therapy was repeatedly withheld because of ongoing inflammation, resulting in prolonged symptoms ...
Takayuki Yamada
wiley +1 more source
Alterations in articular cartilage frictional properties in the setting of acute gouty arthritis.
PLoS ONEThe tribological behaviour of articular cartilage plays a key role in joint motion; however, there is a gap in research on the effect of hyperuricemic joint fluid on cartilage friction behaviour in acute gouty arthritis.
Pai Zheng +7 more
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Cell-based in vitro hemoassay for evaluation of NLRP3-inflammasome activity
Медицинская иммунологияCurrently, gouty arthritis is considered as a polygenic multifactorial autoinflammatory disease caused by activation of the NOD (nucleotide-binding domain) -like protein receptor 3 inflammasome NLRP3.
N. K. Ossina +8 more
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Treat to target in gouty arthritis [PDF]
Vnitřní lékařství, 2018 Gout is a crystal-induced, metabolically determined inflammatory rheumatic disease with increasing prevalence. In clinical practice, gout causes frequent diagnostic as well as therapeutic problems. The golden diagnostic standard is crystalographic analysis and evidence of monosodium urate crystals in the polarization microscope; if this is not ...
openaire +2 more sources
Intelligent design of artificial biocatalyst for biomedical diseases
Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang +3 more
wiley +1 more source