Results 81 to 90 of about 8,646 (202)

Pain Sensitivity Profiles Are Associated With Muscle Biomechanics and Clinical Pain in Persons With Symptomatic Knee Osteoarthritis

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective There is growing evidence that knee osteoarthritis (OA), a significant source of chronic pain, is only partly explained by joint pathophysiology, varies significantly between individuals and may be partly driven by changes in periarticular tissues.
Alisa J. Johnson, Bryce C. Murillo, Yenisel Cruz‐Almeida   +2 more
wiley   +1 more source

Tacrolimus‐Associated Calcium Pyrophosphate Crystal Arthritis in a Kidney Transplant Recipient: An Underrecognized Condition

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Providers who care for renal transplant recipients should be aware of the possibility of tacrolimus‐associated CPPD in patients who present with arthritis. In the case presented, a delayed diagnosis led to the progression of symptoms and avoidable disability, underscoring the need for greater clinical awareness of this condition within the ...
Matthew Wyke, Gabrielle Hitzemann, Sergio M. Maldonado‐Chaar, Veronica A. Ortigosa Serrano, Sachalee Campbell, Franco Cabeza Rivera   +5 more
wiley   +1 more source

Disseminated Chronic Tophaceous Gout With Multi‐Tissue Involvement

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Gout is a metabolic condition in which hyperuricaemia leads to deposition of monosodium urate (MSU) crystals in synovial and peri‐articular tissues. (1) Acutely, synovial deposition causes a painful inflammatory reaction. Over time, chronic hyperuricaemia can lead to deposition of uric acid crystals in alternate tissues, with granulomatous ...
Yee Leng Loh, Fiona Combe
wiley   +1 more source

Septic Arthritis and Its Mimics: Assessing the Incidence, Mortality Rate, Cause‐of Death and Preventability in a Population‐Based Cohort Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Septic arthritis (SA) is considered the most harmful etiology in patients presenting with an acutely painful swollen knee. This study aimed to estimate the incidence, mortality rate, and cause of death among patients diagnosed with SA and compare it to non‐infectious causes.
Amelia Johansson, Omid Bornai, Jonas Tverring, Oskar Ljungquist   +3 more
wiley   +1 more source

Investigating the Relationship Between Dietary Antioxidant Index With Anthropometric Indices, Clinical Symptoms, Inflammatory Markers, Sleep Quality and Quality of Life in Patients With Rheumatoid Arthritis: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation, pain, and deformity, significantly impacting physical and mental well‐being. Sleep disturbances and obesity exacerbate symptoms, increasing disease severity.
Amirabbas Moarefian, Fatemeh Borazjani, Hadi Bazyar, Forough Nokhostin, Ahmad Zare Javid   +4 more
wiley   +1 more source

CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

Nature Communications
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation.
Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu   +16 more
doaj   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Construction and Validation of Plasma Protein‐Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles

Aging Cell, Volume 25, Issue 8, August 2026.
We developed plasma protein‐based musculoskeletal aging clocks, MSKAge and MSKAgeMort, using UK Biobank proteomic data, and showed that MSKAgeAccel and MSKAgeMortAccel (in particular) predicted mortality, musculoskeletal disorders, and age‐related diseases effectively.
Yangdan Zhong, Maoyao Xia, Xunying Zhao, Yang Qu, Bowen Lei, Sirui Zhen, Tao Han, Rong Xiang, Jinyu Xiao, Xin Song, Xiaofeng Ma, Bin Yang, Di Zhang, Jinyu Zhou, Zilan Chen, Yuqi Pang, Ye Ju, Ting Liu, Zihao Li, Lu Long, Tao Zhang, Jiayuan Li, Mengyu Fan, Zuyun Liu, Xia Jiang   +24 more
wiley   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation

Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1301-1311, August 2026.
ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) may mitigate periodontal tissue breakdown through cyclooxygenase (COX) inhibition; however, their long‐term effects on the risk of periodontitis remain unclear. Methods We emulated target trials using US electronic health records (1995–2019) to compare the 5‐year risk of incident ...
Ignacio Leiva‐Escobar, Aiswarya Puzhakkara Chennas, Zoheir Alayash, Stefan Lars Reckelkamm, Birte Holtfreter, Thomas Kocher, Sebastian‐Edgar Baumeister, Michael Nolde   +7 more
wiley   +1 more source

Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.

PLoS ONE
ObjectiveThe Toll-like receptor (TLR) 4-mediated nuclear factor kappa B (NF-κB) signaling pathway regulates the production of inflammatory factors and plays a key role in the pathogenesis of gouty arthritis.
Lu Liu, Shuang He, Lin Jia, Hua Yao, Dan Zhou, Xiaobin Guo, Lei Miao   +6 more
doaj   +1 more source