Results 101 to 110 of about 9,974 (243)

Colchicine Inhibits Chemokine Production in Monosodium Urate–Stimulated Innate Immune Cells

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Objective Colchicine is a well‐established, widely available drug used to treat inflammatory diseases driven by the innate immune system, most notably gout. Although much research has focused on neutrophils, the first responders in a gout flare, monocytes and lymphocytes, also play critical roles in sustaining the inflammatory response.
Laura M. Merlo Pich, Titus Schlüter, Andrei Sarlea, Mihai G. Netea, Calin Popa, Leo A. B. Joosten   +5 more
wiley   +1 more source

Disease Remission: A Scoping Review With Thematic Analysis of the Scientific Literature With Implications for Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, Volume 16, Issue 6, Page 615-629, June 2026.
ABSTRACT Background Remission, a term used to describe a goal of treatment for some chronic diseases, has recently been proposed for chronic rhinosinusitis (CRS). However, it is unclear what remission means for CRS and why it should serve as a goal in the present‐day treatment of CRS.
Nikhil Parail, Lynn Warner, Stacey T. Gray, Claire Hopkins, Peter H. Hwang, Sarah K. Wise, Katie M. Phillips, Ahmad R. Sedaghat   +7 more
wiley   +1 more source

Chlamydia-induced reactive arthritis diagnosed during gout flares [PDF]

, 2019
Rationale:The pathology of gouty arthritis and reactive arthritis (ReA) partially overlaps, and both diseases are characterized by the production of inflammatory cytokines associated with the activation of monocytes and macrophages.
Shin-ya Kawashiri, Igawa, Takashi, Kawakami, Atsushi, Shimizu, Toshimasa, Remi Sumiyoshi, Iwamoto, Naoki, Hideki Nakamura, Takashi Igawa, Koga, Tomohiro, Tamai, Mami, Masataka Umeda, Nishino, Ayako, Umeda, Masataka, Tsuji, Sosuke, Tomoki Origuchi, Yushiro Endo, Sumiyoshi, Remi, Endo, Yushiro, Tomohiro Koga, Kawashiri, Shin-ya, Ayuko Takatani, Mami Tamai, Sosuke Tsuji, Origuchi, Tomoki, Fukui, Shoichi, Takatani, Ayuko, Nakamura, Hideki, Ayako Nishino, Atsushi Kawakami, Naoki Iwamoto, Ichinose, Kunihiro, Toshimasa Shimizu, Shoichi Fukui, Kunihiro Ichinose   +33 more
core   +1 more source

Cell-based in vitro hemoassay for evaluation of NLRP3-inflammasome activity

Медицинская иммунология
Currently, gouty arthritis is considered as a polygenic multifactorial autoinflammatory disease caused by activation of the NOD (nucleotide-binding domain) -like protein receptor 3 inflammasome NLRP3.
N. K. Ossina, L. T. Volova, P. A. Lebedev, I. A. Shafieva, E. I. Pugachev, S. A. Goncharenko, S. I. Kuznetsov, O. A. Gusyakova, G. N. Svetlova   +8 more
doaj   +1 more source

CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

Nature Communications
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation.
Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu   +16 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

A rare and asymptomatic case of mitral valve tophus associated with severe gouty tophaceous arthritis

, 2004
Gouty arthritis is characterized by the deposition of monosodium urate crystals in the joints and soft tissues. Clinical manifestations include acute and chronic arthritis and tophaceous deposits.
Iacobellis, G
core   +1 more source

Bilateral Brucellar Sacroiliitis Mimicking Tuberculous or Inflammatory Spondyloarthropathy: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Brucellosis is a zoonotic infection, endemic in rural areas. It is caused by Brucella species, which are transmitted through the intake of unpasteurized dairy products and contact with infected animals. Sacroiliac joint involvement is common in brucellosis and typically presents as unilateral sacroiliitis. Contrarily, bilateral sacroiliitis is
Zia Ullah, Zain Ul Abedeen, Muhammad Kashif Habib, Naeem Ullah, Abad Ur Rehman   +4 more
wiley   +1 more source

Gouty arthritis in the human aging process

, 2012
The aging process has gained universal recognition and is occurring at an accelerated pace. Gout is a metabolic disorder in which an overproduction and / or decreased excretion of uric acid, leading to the deposition of crystals of sodium monourato ...
Lia Mara Wibelinger, Juliana Secchi Batista   +1 more
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