Results 111 to 120 of about 9,974 (243)

Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa

Feddes Repertorium, Volume 137, Issue 2, June 2026.
ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan, Iliassou L. Mouafon, David R. Katerere   +2 more
wiley   +1 more source

A Systematic Review of Literature: TNF‐α Blockers and JAK Inhibitors for the Treatment of Stevens‐Johnson Syndrome, Toxic Epidermal Necrolysis, and Severe Forms of Erythema Multiforme

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Stevens‐Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and erythema multiforme major (EM major) are severe dermatologic conditions characterized by varying degrees of skin detachment and involvement of mucosal membranes, often triggered by drug reactions or infections.
Sadaf Salehi, Pooneh Torabi, Mahsa Abbaspour, Nima Hajizadeh, Sara Sadeghi, Alireza Jafarzadeh, Azadeh Goodarzi   +6 more
wiley   +1 more source

TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates TCM syndrome differentiation‐guided targeted strategies against NLRP3 inflammasome‐mediated non‐alcoholic fatty liver disease (NAFLD). Metabolic dysfunction and gut‐liver axis dysregulation drive NAFLD progression, activating the NLRP3 inflammasome (comprising NLRP3, ASC, caspase‐1) to trigger cytokine release (IL‐1β,
Yanxia Zhang
wiley   +1 more source

Effect of Long‐Term Non‐Weight Bearing on the Morphology and Function of the Heel Fat Pad

Journal of Foot and Ankle Research, Volume 19, Issue 2, June 2026.
ABSTRACT Background We aimed to investigate the effects of long‐term non‐weight‐bearing conditions, including prolonged bedridden states, on the morphology and function of the heel fat pad. Methods We recruited 13 elderly individuals bedridden for over 1 year (BR group) and 89 age‐matched healthy controls (CON group) living independently.
Toshihiro Maemichi, Masatomo Matsumoto, Toshiharu Tsutsui, Tsukasa Kumai   +3 more
wiley   +1 more source

Total ankle replacement in patients with gouty arthritis

, 2011
Gout is the most common cause of inflammatory arthritis in men and older women. The purpose of this review was to assess prosthetic component stability, postoperative pain relief, functional outcome, and quality of life of patients with gouty ankle ...
Barg, Alexej, Alexej Barg, Kapron, Ashley L., Markus Knupp, Hintermann, Beat, Ashley L Kapron, Knupp, Markus, Beat Hintermann   +7 more
core   +1 more source

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Uji Diagnostik USG untuk Mendiagnosis Gouty Arthritis dibandingkan Baku Emas Analisis Kristal Cairan Sendi.

, 2013
Latar Belakang: Gouty arthritis adalah penyakit keradangan sendi akibat penumpukan kristal monosodium urat. Ditemukannya kristal monosodium urat pada analisis cairan sendi merupakan baku emas diagnosis gouty arthritis.
Rahmawati, Dini
core  

Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study

, 2010
OBJECTIVE: To assess the efficacy and tolerability of canakinumab, a fully human anti-interleukin-1β monoclonal antibody, for the treatment of acute gouty arthritis.
Yücel, A.E., De Meulemeester, M., Valda Murphy, Pikhlak, A., Andrey Pikhlak, Arulmani, U., Peter Sallstig, Dominik Richard, Udayasankar Arulmani, So, A., Murphy, V., A. Eftal Yücel, Naomi Schlesinger, Marc De Meulemeester, Schlesinger, N., Richard, D., Alexander So, Sallstig, P.   +17 more
core   +1 more source

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis

Frontiers in Pharmacology
BackgroundGout, a prevalent and severe form of arthritis precipitated by hyperuricemia, has been the subject of extensive research. However, the intricate underlying mechanisms governing gout-related inflammation are still only partially elucidated ...
Sijing Liu, Sijing Liu, Yongli Situ, Yongli Situ, Li Deng, Li Deng, Meng Liang, Meng Liang, Haoyuan He, Zheng Shao, Zheng Shao, Lifei Peng, Lifei Peng   +12 more
doaj   +1 more source