Results 181 to 190 of about 573,431 (299)

Survivorship of Individuals With Double Heterozygosity for Achondroplasia and Type 2 Collagenopathy

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Historically, double heterozygosity, or a diagnosis of two separate, dominant genetic conditions, was often thought to be lethal in individuals with autosomal dominant skeletal dysplasias. In previously published studies of individuals with dual dysplasia diagnoses of achondroplasia and type 2 collagenopathy, infants died of respiratory ...
Valerie R. Schwartz   +3 more
wiley   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai   +8 more
wiley   +1 more source

Association between rheumatoid arthritis and serum vitamin C levels in Adults: Based on the National health and Nutrition Examination survey database

open access: yesPreventive Medicine Reports
This study attempted to investigate relationship between rheumatoid arthritis and serum vitamin C levels using data from National Health and Nutrition Examination Survey (NHANES).The NHANES database aims to collect health, nutrition, biological, and ...
Jing Zhang   +5 more
doaj  

Arthritis/Rheumatoid Arthritis

open access: yes, 2017
Esma Özkan   +2 more
openaire   +4 more sources

Application of humanized mice in the safety experiments of antibody drugs

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun   +9 more
wiley   +1 more source

Comorbidity in incident rheumatoid arthritis: a nationwide case-control study with bidirectional follow-up. [PDF]

open access: yesRheumatology (Oxford)
Batko B   +13 more
europepmc   +1 more source

Rheumatoid Arthritis [PDF]

open access: yesPostgraduate Medical Journal, 1948
openaire   +2 more sources

Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat   +6 more
wiley   +1 more source

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