Results 51 to 60 of about 48,742 (271)

Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae.

Frontiers in Cellular and Infection Microbiology, 2013
Bartonella are hemotropic bacteria responsible for emerging zoonoses. Most Bartonella species appear to share a natural cycle that involves an arthropod transmission, followed by exploitation of a mammalian host in which they cause long-lasting intra ...
Francis eBiville, Ma Feng eLiu
doaj   +1 more source

Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

Vaccines, 2021
Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials.
Valéria L. Carvalho, Maureen T. Long
doaj   +1 more source

Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]

, 2014
BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A, Clarke, Thomas H, Garb, Jessica E, Haney, Robert A, Hayashi, Cheryl Y   +4 more
core   +2 more sources

Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases [PDF]

Journal of Biomedicine and Biotechnology, 2010
One approach to identify epitopes that could be used in the design of vaccines to control several arthropod-borne diseases simultaneously is to look for common structural features in the secretome of the pathogens that cause them. Using a novel bioinformatics technique, cysteine-abundance and distribution analysis, we found that many different proteins
Mejia, J. Santiago, Arthun, Erik N., Titus, Richard G.   +2 more
openaire   +2 more sources

The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway

mBio, 2022
The ability of an arthropod to harbor and transmit pathogens is termed “vector competency.” Many factors influence vector competency, including how arthropod immune processes respond to the microbe. Divergences in innate immunity between arthropods are increasingly being reported.
Lindsay C. Sidak-Loftis, Kristin L. Rosche, Natasha Pence, Jessica K. Ujczo, Joanna Hurtado, Elis A. Fisk, Alan G. Goodman, Susan M. Noh, John W. Peters, Dana K. Shaw   +9 more
openaire   +3 more sources

Cryptic Genes for Interbacterial Antagonism Distinguish Rickettsia Species Infecting Blacklegged Ticks From Other Rickettsia Pathogens

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThe genus Rickettsia (Alphaproteobacteria: Rickettsiales) encompasses numerous obligate intracellular species with predominantly ciliate and arthropod hosts.
Victoria I. Verhoeve, Tyesha D. Fauntleroy, Riley G. Risteen, Timothy P. Driscoll, Joseph J. Gillespie   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The evolution and comparative neurobiology of endocannabinoid signalling [PDF]

, 2012
CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A., Maurice R. Elphick, Montell C., Soderstrom K., Soderstrom K.   +4 more
core   +1 more source

Characterizing bacteriophage proteins that hijack arthropod reproduction

, 2020
Wolbachia are maternally-inherited symbionts that cause cytoplasmic incompatibility (CI). Dual expression of the two phage WO genes cifA and cifB in males causes CI, while expression of cifA in females rescues CI. Structural homology-based analyses suggest that CifA and CifB proteins have three putative functional domains each, but the relative ...
J. Dylan Shropshire, Mahip Kalra, Bordenstein, Seth   +2 more
openaire   +1 more source

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source