Results 101 to 110 of about 441,477 (379)
A scaffold-free approach to cartilage tissue generation using human embryonic stem cells
Scientific Reports, 2021 Articular cartilage functions as a shock absorber and facilitates the free movement of joints. Currently, there are no therapeutic drugs that promote the healing of damaged articular cartilage. Limitations associated with the two clinically relevant cell
Lauren A. Griffith +4 more
doaj +1 more source
Vibrational spectroscopy of articular cartilage
, 2017 Articular cartilage is a connective tissue that is located at the ends of long bones. Type II collagen, proteoglycans, water, and chondrocytes are the main constituents of articular cartilage.
L. Rieppo, J. Töyräs, S. Saarakkala
semanticscholar +1 more source
Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study
, 2014 Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity, dedifferentiation and limited lifespan associated with the use of articular chondrocytes for cartilage repair.
Li, Siwei +3 more
core +1 more source
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source
The presence and degradation of nerve fibers in articular cartilage of neonatal rats
Journal of Orthopaedic Surgery and Research, 2022 Purpose To investigate the presence and change of nerve fibers and neuropeptide during early development of articular cartilage in neonatal rats. Methods Articular cartilage in distal-femoral epiphyses was collected from neonatal Sprague Dawley rats ...
Zheng Wang +4 more
doaj +1 more source
The Effect of Mechanical Loading on Articular Cartilage
, 2016 The effect of mechanical loading on articular cartilage is the topic chosen for the second editorial of this newly launched journal. The aim of this interesting editorial is to illustrate the cell signaling correlated to the mechanical loading, some ...
G. Musumeci
semanticscholar +1 more source
The Effect of Intra-articular Corticosteroids on Articular Cartilage
Orthopaedic Journal of Sports Medicine, 2015 Background: Intra-articular (IA) corticosteroid therapy has been used for the treatment of inflammation and pain in the knee since the 1950s. Purpose: To review the current literature on the effects of IA corticosteroids on articular cartilage.
Chloe Wernecke, H. Braun, J. Dragoo
semanticscholar +1 more source
Advanced Science, EarlyView.MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie +15 more
wiley +1 more source
Articular cartilage and changes in Arthritis: Collagen of articular cartilage [PDF]
Arthritis Research & Therapy, 2001 The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix.
openaire +1 more source
Advanced Science, EarlyView.Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen +12 more
wiley +1 more source