Results 51 to 60 of about 110,448 (314)

Computational modelling of fluid load support in articular cartilage [PDF]

, 2013
Natural articular cartilage is known to be an excellent bearing material with very low friction coefficient and wear rate. Theoretical and experimental studies have demonstrated that the interstitial fluid of cartilage is pressurized considerably ...
An, Shuqiang
core  

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

Research progress of self-assembling peptide hydrogels in repairing cartilage defects

Frontiers in Materials, 2022
Due to the lack of blood vessels, nerves and lymphatic vessels, the capacity of articular cartilage to heal is extremely limited. Once damaged, it is urgent for articular cartilage to repair the injury.
Renyi Wang, Renyi Wang, Yuhao Wang, Yuhao Wang, Han Yang, Chengzhi Zhao, Chengzhi Zhao, Jian Pan, Jian Pan   +8 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Does radiofrequency ablation (RFA) epiphysiodesis affect adjacent joint cartilage?

Journal of Children's Orthopaedics, 2016
Purpose To test the hypothesis that epiphysiodesis made with radiofrequency ablation (RFA) is a safe procedure that disrupts the growth plate without damaging the adjacent joint articular cartilage.
Juan Manuel Shiguetomi-Medina, O. Rahbek, A. A. H. Abood, H. Stødkilde-Jørgensen, J. L. Ramírez Garcia-Luna, B. Møller-Madsen   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Recent progress of hydrogel-based biomimetic articular cartilage in mechanical and lubricated enhancement

Friction
Articular cartilage covering a joint surface provides excellent lubrication and a load-bearing interface for the daily activities of the human body, which is characterized by high load-bearing, low friction, and wear resistance.
Qin Chen, Kai Chen, Xinyue Zhang, Haiyan Feng, Cunao Feng, Xiaowei Li, Dekun Zhang   +6 more
doaj   +1 more source

Cartilaginous Organoids: Advances, Applications, and Perspectives

Advanced NanoBiomed Research, 2023
Cartilage is a nonvascular and non‐neural, mesoderm‐derived tissue. Cartilage repair, especially articular cartilage repair and reconstruction, has always been a difficult problem in bone tissue engineering.
Yuhao Yu, Juan Wang, Yamin Li, Yunsu Chen, Wenguo Cui   +4 more
doaj   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Injectable hypoxia-preconditioned cartilage progenitor cells-laden GelMA microspheres system for enhanced osteoarthritis treatment

Materials Today Bio, 2023
Osteoarthritis (OA) is the most common age-related degenerative joint disease mainly characterized by the destruction of articular cartilage. Owing to its native avascular property, intrinsic repair of articular cartilage is very limited.
Kai Feng, Yifan Yu, Zhengsheng Chen, Feng Wang, Kunqi Zhang, Hongfang Chen, Jia Xu, Qinglin Kang   +7 more
doaj   +1 more source