Results 31 to 40 of about 110,448 (314)

Direct Visualisation of the Depth-Dependent Mechanical Properties of Full-Thickness Articular Cartilage.

, 2012
The structural anisotropy of articular cartilage controls its deformation response. As proteoglycans and collagen vary with depth, simple uniaxial compression results in inhomogeneous deformation with distinct depth-dependent mechanical properties ...
Szarko, M, Xia, Y
core   +1 more source

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

Bioactive Materials, 2023
Lacking self-repair abilities, injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular ...
Yucong Li, Linlong Li, Ming Wang, Boguang Yang, Baozhen Huang, Shanshan Bai, Xiaoting Zhang, Nan Hou, Haixing Wang, Zhengmeng Yang, Chong Tang, Ye Li, Wayne Yuk-Wai Lee, Lu Feng, Micky D. Tortorella, Gang Li   +15 more
doaj   +1 more source

Tracking Spatiotemporal Extracellular Matrix Evolution and Tissue Fusion in 3D Microtissues via Click Chemistry‐Based Metabolic Labelling

Advanced Healthcare Materials, EarlyView.
Metabolic labeling of nascent proteins in 3D microtissue spheroids provides a powerful analytical approach for large‐scale tissue engineering. Incorporation of non‐canonical amino acids with fluorescent tagging enables spatiotemporal investigation of extracellular matrix deposition and its evolution during multicellular tissue development and fusion ...
Theresa Koenig, F. Max Yavitt, Laura Veenendaal, Tim B. F. Woodfield   +3 more
wiley   +1 more source

Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair

Materials Today Bio
Untreated articular cartilage injuries often result in severe chronic pain and dyskinesia. Current repair strategies have limitations in effectively promoting articular cartilage repair, underscoring the need for innovative therapeutic approaches. A gene-
Min Wang, Jiachen Wang, Xin Xu, Erliang Li, Peng Xu   +4 more
doaj   +1 more source

Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics.

PLoS ONE, 2015
Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune ...
Venkatachalam Natarajan, Balaraman Madhan, Moti L Tiku   +2 more
doaj   +1 more source

Effects of low tangential permeability in the superficial layer on the frictional property of articular cartilage

Biosurface and Biotribology, 2015
The biphasic characteristics of articular cartilage are known to play important roles in cartilage lubrication. However, it is still difficult to biotribologically explain the extremely low friction coefficient observed in articular cartilage.
H. Fujie, K. Imade
doaj   +1 more source

Gene expression profiling reveals similarities between the spatial architectures of postnatal articular and growth plate cartilage. [PDF]

PLoS ONE, 2014
Articular and growth plate cartilage are discrete tissues but arise from a common cartilaginous condensation and have comparable spatial architectures consisting of distinct layers of chondrocytes.
Michael Chau, Julian C Lui, Ellie B M Landman, Stephan-Stanislaw Späth, Andrea Vortkamp, Jeffrey Baron, Ola Nilsson   +6 more
doaj   +1 more source

Standardized Effect Measures Informing Next‐Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen, Tony B. Huang, Catherine E. Davey, Elias Salzer, Gerjo J. V. M. Van Osch, Sandra J. Shefelbine, Marcus G. Pandy, Kathryn S. Stok   +7 more
wiley   +1 more source

Contact mechanics modelling of articular cartilage and applications [PDF]

, 2006
Osteoarthritis (OA) is a degenerative disease of articular cartilage. The normal cartilage is known to be an excellent bearing material with remarkable lubricating properties and very low frictional co-efficient and wear and generally survives the ...
Pawaskar, Sainath Shrikant
core  

Contribution of postnatal collagen reorientation to depth-dependent mechanical properties of articular cartilage

, 2011
The collagen fibril network is an important factor for the depth-dependent mechanical behaviour of adult articular cartilage (AC). Recent studies show that collagen orientation is parallel to the articular surface throughout the tissue depth in perinatal
Kranenbarg, S., Turnhout, M.C., van, Leeuwen, J.L., van   +2 more
core   +1 more source