Results 81 to 90 of about 457,350 (333)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Nanofibrous poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) scaffolds provide a functional microenvironment for cartilage repair [PDF]

, 2016
Articular cartilage defects, when repaired ineffectively, often lead to further deterioration of the tissue, secondary osteoarthritis and, ultimately, joint replacement.
Andriotis, Orestis G., Basnett, Pooja, Ching, Kuan Y., Li, Siwei, Roy, Ipsita, Sengers, Bram G., Stolz, Martin, Su, Bo, Tare, Rahul S.   +8 more
core   +2 more sources

In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

Scientific Reports, 2016
The in vivo measurement of articular cartilage deformation is essential to understand how mechanical forces distribute throughout the healthy tissue and change over time in the pathologic joint.
D. Chan, L. Cai, Kent D. Butz, S. Trippel, E. Nauman, C. Neu   +5 more
semanticscholar   +1 more source

LipoGels: Robust Self‐Lubricating Physically Cross‐Linked Alginate Hydrogels Embedded with Liposomes

Advanced Functional Materials, EarlyView.
Physically cross‐linked alginate hydrogels embedded with 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine liposomes (LipoGels) are prepared under optimized conditions to avoid shrinkage and achieve structural uniformity. LipoGels demonstrate robust mechanical strength (Young's modulus ≈1 MPa), excellent lubrication (friction coefficient ≈0.021), and ...
Tao Ma, Xueying Guo, Najet Mahmoudi, Pierangelo Gobbo, Wuge H. Briscoe   +4 more
wiley   +1 more source

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. [PDF]

, 2018
Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases.
Baek, Balemans, Baron, Bouaziz, Chan, Chang, Christiansen, Collette, Collette, Dejour, Glasson, Goldring, Hwang, Itin, Kapoor, Karlsson, Li, Li, Livak, Lockwood, Loeser, Lohmander, Loots, Mabey, Ovcharenko, Ratzlaff, Reppe, Rigoglou, Roudier, Sokolove, Swarnkar, Trapnell, Trapnell, Trapnell, van Dinther, Velasco, Wehmeyer, Zhu   +37 more
core   +2 more sources

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

A homeostatic function of CXCR2 signalling in articular cartilage [PDF]

, 2014
Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen, Bertrand, J, Brandolini, L, De Bari, C, Dell'Accio, F, Dompe SPA, Karystinou, A, KU Leuven, Luyten, F P, Muenster, Nalesso, G, Pap, T, Pitsillides, A A, Pitzalis, C, Poulet, B, Queen Mary London, Sherwood, J, UCL   +17 more
core   +2 more sources

Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis

Orthopaedic Journal of Sports Medicine, 2017
Background: Osteoarthritis (OA) currently affects 10% of the American population. There has been a recent push to determine exactly what causes OA and how it can be treated most effectively.
Rachel Garfinkel, Matthew F. Dilisio, D. Agrawal   +2 more
semanticscholar   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes

Stem Cells International, 2017
Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity.
Jie Shi, Jiulong Liang, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao   +6 more
doaj   +1 more source