Results 81 to 90 of about 176,243 (319)
Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]
, 2015 Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi +3 more
core +1 more source
Advanced Science, EarlyView.Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian +26 more
wiley +1 more source
Genipin crosslinking decreases the mechanical wear and biochemical degradation of impacted cartilage in vitro [PDF]
, 2016 High energy trauma to cartilage causes surface fissures and microstructural damage, but the degree to which this damage renders the tissue more susceptible to wear and contributes to the progression of post-traumatic osteoarthritis (PTOA) is unknown ...
Bonitsky, Craig M. +5 more
core +1 more source
Advanced Science, EarlyView.Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce +8 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
THE THERAPEUTIC TACTICS OF INTRA-ARTICULAR FRACTURES OF THE ANKLE (LITERATURE REVIEW)
Acta Biomedica Scientifica, 2013 As a result of the analysis of literature it was revealed that in case of pronation-abduction ankle injury takes place injury of the articular surfaces. The hyaline cartilage significantly suffers.
I. V. Zedgenidze, N. V. Tishkov
doaj
Arthroscopic Evaluation of Knee Cartilage Using Optical Reflection Spectroscopy
Arthroscopy Techniques, 2019 Articular cartilage is critical for painless and low-friction range of motion; however, disruption of articular cartilage, particularly in the knee joint, is common.
Justin L. Makovicka, M.D. +5 more
doaj +1 more source
Advanced Science, EarlyView.FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu +12 more
wiley +1 more source
Modeling and Simulation of the Effects of Cyclic Loading on Articular Cartilage Lesion Formation
, 2013 We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al.
Ayati, Bruce P. +5 more
core
Advanced Science, EarlyView.A dynamic granular system composed of microgels crosslinked through guest‐host interactions is developed to reversibly alter its stiffness and microporosity in response to chemical stimuli, enabling temporal regulation of cell migration. Suspension bioprinting using this dynamic hydrogel allows for 4D spatiotemporal control over tissue formation ...
Keisuke Nakamura +4 more
wiley +1 more source