Results 181 to 190 of about 43,162 (263)

The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. [PDF]

Front Immunol, 2018
Lee SY, Lee SH, Na HS, Kwon JY, Kim GY, Jung K, Cho KH, Kim SA, Go EJ, Park MJ, Baek JA, Choi SY, Jhun J, Park SH, Kim SJ, Cho ML.   +15 more
europepmc   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Knotless suture anchor fixation of Hahn-Steinthal fractures of the capitellum: A technical note with preliminary clinical outcomes. [PDF]

SICOT J
Szufnara M, Ciesielski M, Wójtowicz B, Poszepczyński J, Domżalski M, Lesman J.   +5 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Novel therapeutic strategies for osteoarthritis: from mechanistic insights to precision medicine. [PDF]

Bone Res
Umar M, Wang Z, Li J, Li Z, Li G, Tong L, Chen D.   +6 more
europepmc   +1 more source

Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives

iRADIOLOGY, EarlyView.
This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo, Yuling Cui, Zhiye Fan, Chenxin Jiang, Bowen Fu, Guangbin Cui, Yanli He   +6 more
wiley   +1 more source

Intra-Articular Cyclo(His-Pro) Attenuates Monosodium Iodoacetate-Induced Osteoarthritis by Suppressing COX-2/PGE₂ Signaling and Cartilage Catabolism in Rats. [PDF]

Int J Mol Sci
Huh G, Lee D, Jeon J, Kim D, Jung HY.
europepmc   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

The Effect of Retrograde Intramedullary Nail Entry at the Metacarpal Head on Metacarpophalangeal Joint Contact Mechanics. [PDF]

J Hand Surg Glob Online
Hollenbeck JFM, Castro RR, Mukohara S, Perleberg TD, Viola RW.   +4 more
europepmc   +1 more source

Microfracture for full‐thickness chondral lesions of the knee in elite athletes leads to high return‐to‐play rates

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Injuries to the knee are common in elite athletes and often involve damage to the articular cartilage. Given the high demands of elite sport, full‐thickness articular cartilage defects in the knee can be career‐limiting or threatening.
David J. Haslhofer, Jobe Shatrov, Mary Jones, Wahid Abdul, Arman Motesharei, Simon V. Ball, Andy Williams   +6 more
wiley   +1 more source