The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. [PDF]
Front Immunol, 2018 Osteoarthritis (OA) is a degenerative disease that induces pain, cartilage deformation, and joint inflammation. Mesenchymal stem cells (MSCs) are potential therapeutic agents for treatment of OA.
Lee SY +15 more
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Resurfacing damaged articular cartilage to restore compressive properties [PDF]
Journal of Biomechanics, 2014 Surface damage to articular cartilage is recognized as the initial underlying process causing the loss of mechanical function in early-stage osteoarthritis. In this study, we developed structure-modifying treatments to potentially prevent, stabilize or reverse the loss in mechanical function.
Stéphanie Grenier +3 more
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TGF-β1 Improves Articular Cartilage Damage in Rabbit Knee [PDF]
Pakistan Veterinary Journal, 2012 The present study was designed to assess the role of TGF-β1 in cartilage repair in an in vivo model of articular cartilage defect in rabbit. Twenty four New Zealand white rabbits of either sex, 6-7 months old (1-2 kgs) were divided into two groups i.e. A
N. K. Singh, S. Shiwani1, G. R. Singh2, D. K. Jeong3, P. Kinjavdekar4, Amarpal4, J. D. Lohakare and S. J. Lee*
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Are There Racial Disparities in Knee Symptoms and Articular Cartilage Damage in Patients Presenting for Arthroscopic Partial Meniscectomy? [PDF]
JBJS Open Access, 2022 Background:. The purpose of the present study was to examine whether Black patients presenting for arthroscopic partial meniscectomy (APM) have worse baseline knee pain, worse knee function, and greater articular cartilage damage than White patients ...
Christa L. Wentt, MD +5 more
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The effect of loading rate on the development of early damage in articular cartilage [PDF]
Biomechanics and Modeling in Mechanobiology, 2016 Experimental reports suggest that cartilage damage depends on strain magnitude. Additionally, because of its poro-viscoelastic nature, strain magnitude in cartilage can depend on strain rate.
J.M. Párraga Quiroga +3 more
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Immobilization ameliorates chemically‐induced articular cartilage damage [PDF]
Arthritis & Rheumatism, 1984 AbstractWe have previously shown that immobilization protects against the development of mechanically‐induced osteoarthritis following anterior cruciate ligament transection in dogs. Herein, we examine the effect of immobilization of the leg on the chemically‐induced degeneration of femoral articular cartilage caused by intraarticular injection of ...
J M, Williams, K D, Brandt
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Diffusion-Tensor Imaging of Human Articular Cartilage Specimens with Early Signs of Cartilage Damage [PDF]
Radiology, 2013 To assess the use of diffusion-tensor (DT) imaging of articular cartilage to detect and grade early cartilage damage in human specimens with early signs of cartilage damage.This study was approved by the institutional review board. Forty-three cartilage-on-bone samples drilled from 21 human patellae were examined with 17.6-T magnetic resonance (MR ...
José G, Raya +9 more
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Causes of mechanically induced collagen damage in articular cartilage [PDF]
Journal of Orthopaedic Research, 2005 AbstractOsteoarthritis (OA) is a multifactorial disease, associated with articular cartilage degeneration and eventually joint destruction. The phases of the disease have been described in detail, and mechanical factors play an important role in the initiation of OA, but many questions remain about its etiology.
W. Wilson +5 more
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The Intra-Articular Hematoma Immediately after Ankle Fracture Causes Cartilage Damage That is Partially Attenuated by Anti-Inflammatory Agents [PDF]
Foot & Ankle Orthopaedics, 2020 Category: Ankle Arthritis; Basic Sciences/Biologics Introduction/Purpose: Post-traumatic osteoarthritis (PTOA) is a frequent cause of disability. The most common predisposing factor for ankle PTOA is intra-articular ankle fracture.
Samuel B. Adams MD +2 more
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Probing articular cartilage damage and disease by quantitative magnetic resonance imaging [PDF]
Journal of The Royal Society Interface, 2013 Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical, biomechanical, metabolic and genetic factors, which are often triggered by injury, and mediated by inflammation, catabolic cytokines and enzymes.
Deva D, Chan, Corey P, Neu
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