Results 101 to 110 of about 650,432 (282)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Mechanical Engineering Design Project report: Enabler control systems [PDF]

open access: yes
The Controls Group was assigned the responsibility for designing the Enabler's control system. The requirement for the design was that the control system must provide a simple user interface to control the boom articulation joints, chassis articulation ...
Cullen, Christian   +3 more
core   +1 more source

A Constructive Model of Mother-Infant Interaction towards Infant’s Vowel Articulation [PDF]

open access: yes, 2003
Human infants seem to develop to acquire common phonemes to adults without the capability to articulate or any explicit knowledge. To understand such unrevealed human cognitive development, building a robot which reproduces such a developmental process ...
Asada, Minoru   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Articulation

open access: yes, 1996
Abstract Articulation, says the dictionary definition, is “the art or process of speaking.” The definition applies to flute playing just as it applies to verbal utterance. The components-breath, rhythm, accent, phrasing, termination, and silence-are the same, as are the tools-the respiratory system, lips, and tongue.
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

An Interface for Open-Ended Design in Housing Production: An Analysis of Yeşilköy Housing by the Context of Adaptability

open access: yesJournal of Architectural Sciences and Applications
Housing can be regarded as a field of production that directly reflects changes in individual life while serving as a significant indicator of broader social transformations. This study conceptualizes housing as an open-ended product within the framework
Güldehan Atay, Melike Yenice Yıldız
doaj   +1 more source

Comparing inductive and deductive methodologies for design patterns identification and articulation [PDF]

open access: yes, 2007
Design patterns offer a valuable format to communicate knowledge of successful design solutions to recurring problems. However, there is a lack of research into design patterns that differentiate the applicability of the proposed design solutions across ...
Jachna, Timothy, Schadewitz, Nicole
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Voice and speech functions (B310-B340) [PDF]

open access: yes, 2012
The International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY) domain ‘voice and speech functions’ (b3) includes production and quality of voice (b310), articulation functions (b320), fluency and rhythm of speech ...
McCartney, Elspeth
core  

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