Results 81 to 90 of about 769,096 (329)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

DRAP : un test de Dépistage Rapide de l’Articulation et de la Parole pour les enfants de 3 à 6 ans

Glossa, 2021
Cet article décrit un nouveau test de dépistage, le DRAP, qui permet d’évaluer de manière rapide l’articulation et la phonologie des enfants francophones âgés de 3 à 6 ans.
Nathalie Niederberger, Margaret Kehoe, Anne-Laure Bouchut   +2 more
doaj  

Surface palatalization of polish bilabial stops : articulation and acoustics [PDF]

, 2003
Bilabial stops undergoing Surface Palatalization (SP) were analyzed in an EMMA/EPG study. Articulatorily, the point of maximal palatal contact and the labial opening movement were analyzed.
Pompino-Marschall, Bernd, Zygis, Marzena
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Enhancing the Effectiveness of Social Dialogue Articulation in Europe (EESDA) Project No. VS/2017/0434 Social Dialogue Articulation and Effectiveness: Country Report for France [PDF]

, 2017
This report presents a country study analysing the articulation and effectiveness of social dialogue in France. The methodological approach relies on desk research and semi-structured interviews with social partners in France, aiming at obtaining deeper ...
Akgüç, Mehtap, Jacquot, Manon, Lopez-Uroz, Nina   +2 more
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Speech characteristics of monozygotic twins and a same-sex sibling: an acoustic case study of coarticulation patterns in read speech [PDF]

, 2003
This case study reports on an acoustic investigation of the motor speech characteristics of a set of young adult male monozygotic (MZ) twins and compares them to those of an age- and sex-matched sibling who participated in the study 2 years later to ...
Rixon, E., Whiteside, S.P.
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Communication disorders in individuals with cleft lip and palate: An overview

Indian Journal of Plastic Surgery, 2009
The need for an interdisciplinary approach in the comprehensive management of individuals with cleft lip and palate is well recognized. This article provides an introduction to communication disorders in individuals with cleft lip and palate for members ...
Roopa Nagarajan, V. H. Savitha, B. Subramaniyan   +2 more
doaj   +1 more source