Results 71 to 80 of about 1,104,325 (338)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Studying complex adaptive systems using molecular classifier systems [PDF]
, 2007 Complex Adaptive Systems (CAS) are dynamical networks of interacting agents occurring in a variety of natural and artificial systems (e.g. cells, societies, stock markets). These complex systems have the ability to adapt, evolve and learn from experience.
Decraene, James +2 more
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Artificial cells: prospects for biotechnology [PDF]
Trends in Biotechnology, 2002 A variety of techniques can now be used to alter the genome of a cell. Although these techniques are very powerful, they have limitations related to cost and efficiency of scale. Artificial cells designed for specific applications combine properties of biological systems such as nanoscale efficiency, self-organization and adaptability at relatively low
Andrew, Pohorille, David, Deamer
openaire +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 It is only in the last 20 years that many of the original ideas on artificial cells are being increasingly applied and extended by researchers around the world.
Thomas Ming Swi Chang
doaj +1 more source
, 2012 We study theoretically the hydrodynamics of a fluid drop containing oriented filaments endowed with active contractile or extensile stresses and placed on a solid surface.
DeGennes +4 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A four-track perspective for bottom-up synthetic cells
Frontiers in Bioengineering and Biotechnology, 2022 Pasquale Stano
doaj +1 more source
T cell recognition of nonpolymorphic determinants on H-2 class I molecules. [PDF]
, 1988 Recognition of polymorphic determinants on class I or class II MHC Ag is required for T lymphocyte responses. Using cell-size artificial membranes (pseudocytes) bearing H-2 class I Ag it is demonstrated that T cells can, in addition, recognize ...
Goldstein, SA, Mescher, MF
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