In silico transitions to multicellularity
, 2014 The emergence of multicellularity and developmental programs are among the major problems of evolutionary biology. Traditionally, research in this area has been based on the combination of data analysis and experimental work on one hand and theoretical ...
Duran-Nebreda, Salva, Solé, Ricard V.
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Automatic Programming of Cellular Automata and Artificial Neural Networks Guided by Philosophy
, 2020 Many computer models such as cellular automata and artificial neural networks have been developed and successfully applied. However, in some cases, these models might be restrictive on the possible solutions or their solutions might be difficult to ...
A Ilachinski +9 more
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A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]
, 2015 Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco +9 more
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Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
A four-track perspective for bottom-up synthetic cells
Frontiers in Bioengineering and Biotechnology, 2022 Pasquale Stano
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A Non-dissipative Reconstruction Scheme for the Compressible Euler Equations [PDF]
, 2014 We present a finite volume scheme, first on the Burgers equations, then on the Euler equations, based on a conservative reconstruction of shocks inside each cells of the mesh. Its main features are the following points.
Aguillon, Nina
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Antimicrobial activity of an iron triple helicate [PDF]
, 2009 The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections.
Adair D. Richards +15 more
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Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Pier Luigi Gentili, Pasquale Stano
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Chemical communication between synthetic and natural cells: a possible experimental design [PDF]
, 2013 The bottom-up construction of synthetic cells is one of the most intriguing and interesting research arenas in synthetic biology. Synthetic cells are built by encapsulating biomolecules inside lipid vesicles (liposomes), allowing the synthesis of one or ...
D'Angelo, Francesca +5 more
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