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Rethinking governance of synthetic cells [PDF]

Frontiers in Bioengineering and Biotechnology
Synthetic cells represent a class of engineered biological systems that span a continuum from non-replicating biochemical assemblies to genome-containing entities, exposing limitations in conventional approaches to biotechnology governance. These systems
David R. Gillum, Peter A. Carr, India Hook-Barnard, Trisha Tucholski   +3 more
doaj   +5 more sources

Synthetic cells by the numbers [PDF]

iScience
Summary: Can we build a living cell from non-living molecular components? This foundational question drives the field of synthetic cell engineering, having already reconstituted key cellular processes within synthetic environments, and now advancing ...
Chana G. Sokolik, Maya Bar-Dolev, Ron Milo, Katarzyna P. Adamala, Michael Levy   +4 more
doaj   +5 more sources

Light‐Based Juxtacrine Signaling Between Synthetic Cells [PDF]

Small Science
Cell signaling through direct physical cell–cell contacts plays vital roles in biology during development, angiogenesis, and immune response. Intercellular communication mechanisms between synthetic cells constructed from the bottom up are majorly ...
Hossein Moghimianavval, Kyle J. Loi, Sung‐Won Hwang, Yashar Bashirzadeh, Allen P. Liu   +4 more
doaj   +3 more sources

Light-Controlled Membrane Fusion in Synthetic Cells [PDF]

Life
Light-induced membrane fusion has become a pivotal technique for constructing and functionalizing synthetic cells by enabling precise control over membrane merging events.
Boying Xu, Adriano Caliari, Jian Xu
doaj   +2 more sources

Build-a-Cell: Engineering a Synthetic Cell Community [PDF]

Life, 2021
Build-a-Cell is a global network of researchers that aims to develop synthetic living cells within the next decade. These cells will revolutionize the biotechnology industry by providing scientists and engineers with a more complete understanding of ...
Caroline Frischmon, Carlise Sorenson, Michael Winikoff, Katarzyna P. Adamala   +3 more
doaj   +3 more sources

Synthetic cells for phage therapy: a perspective [PDF]

Frontiers in Cellular and Infection Microbiology
A synthetic cell is a membrane-bound vesicle that encapsulates cell-free transcription/translation (TXTL) systems. It represents a transformative platform for advancing bacteriophage therapy.
Vishwesh Kulkarni, Vishwesh Kulkarni, Nadanai Laohakunakorn, Sahan B. W. Liyanagedera, Sahan B. W. Liyanagedera   +4 more
doaj   +2 more sources

Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells [PDF]

Advanced Science
Natural killer (NK) cells are critical components of the first‐line immune defense, responsible for eliminating tumorigenic cells. NK cell‐based adoptive immunotherapy has gained increasing attention; however, cryopreservation, a standard technique for ...
Xiangda Zhou, Sijia Zhang, Wenjuan Yang, Susanne Gonder, Zeinab Sadjadi, Nils Piernitzki, Alina Moter, Shulagna Sharma, Anne Largeot, Nadja Küchler, Lea Kaschek, Gertrud Schäfer, Eva C. Schwarz, Hermann Eichler, Evelyn Ullrich, Heiko Rieger, Oskar Staufer, Jérôme Paggetti, Etienne Moussay, Markus Hoth, Bin Qu   +20 more
doaj   +2 more sources

Synthetic Cells Engaged in Molecular Communication: An Opportunity for Modelling Shannon- and Semantic-Information in the Chemical Domain

Frontiers in Communications and Networks, 2021
In this Perspective article we intend to focus on the opportunity of modelling Shannon information and/or “semantic” information in the field originated by the convergence of bottom-up synthetic biology (in particular, the construction of “synthetic ...
Maurizio Magarini, Pasquale Stano
doaj   +1 more source

A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?

Molecules, 2023
The potential role of bottom-up Synthetic Cells (SCs) in the Internet of Bio-Nano Things (IoBNT) is discussed. In particular, this perspective paper focuses on the growing interest in networks of biological and/or artificial objects at the micro- and ...
Pasquale Stano, Pier Luigi Gentili, Luisa Damiano, Maurizio Magarini   +3 more
doaj   +1 more source

Synthetic Genomics From a Yeast Perspective

Frontiers in Bioengineering and Biotechnology, 2022
Synthetic Genomics focuses on the construction of rationally designed chromosomes and genomes and offers novel approaches to study biology and to construct synthetic cell factories.
Charlotte C. Koster, Eline D. Postma, Ewout Knibbe, Céline Cleij, Céline Cleij, Pascale Daran-Lapujade   +5 more
doaj   +1 more source