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Synthetic cells by the numbers [PDF]
iScienceSummary: Can we build a living cell from non-living molecular components? This foundational question drives the field of synthetic cell engineering, having already reconstituted key cellular processes within synthetic environments, and now advancing ...
Chana G. Sokolik +4 more
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Synthetic cells for phage therapy: a perspective [PDF]
Frontiers in Cellular and Infection MicrobiologyA synthetic cell is a membrane-bound vesicle that encapsulates cell-free transcription/translation (TXTL) systems. It represents a transformative platform for advancing bacteriophage therapy.
Vishwesh Kulkarni +4 more
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The bioethics of synthetic cells
Nature Reviews Molecular Cell Biology, 2023 The Building a Synthetic Cell (BaSyC) consortium — launched in 2017 — proposes to create “an autonomous self-reproducing cell that can sustain itself, replicate and divide”. I joined this consortium to explore the bioethics of creating synthetic cells, by embedding philosophical reflection into research practices.
Hub Zwart, Zwart Hub
exaly +4 more sources
Controlling Synthetic Cell-Cell Communication [PDF]
Frontiers in Molecular Biosciences, 2022 Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide application, for instance in studying cellular communication and as delivery devices to living cells. However, to fully realise the potential of synthetic cells,
Jefferson M. Smith +2 more
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Build-a-Cell: Engineering a Synthetic Cell Community [PDF]
Life, 2021 Build-a-Cell is a global network of researchers that aims to develop synthetic living cells within the next decade. These cells will revolutionize the biotechnology industry by providing scientists and engineers with a more complete understanding of ...
Caroline Frischmon +3 more
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On the “Life-Likeness” of Synthetic Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 One of the most exciting and rapidly expanding research area incontemporary science isthe bottom-up construction of artificial cell-like systems, also known as synthetic cells. Suchapproaches are part of the synthetic biology research paradigm, which equates to understandingmeans constructing. Accordingly, these artificial systemsare considered able to
Luisa Damiano, Pasquale Stano
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Light-Controlled Membrane Fusion in Synthetic Cells [PDF]
LifeLight-induced membrane fusion has become a pivotal technique for constructing and functionalizing synthetic cells by enabling precise control over membrane merging events.
Boying Xu, Adriano Caliari, Jian Xu
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Light‐Based Juxtacrine Signaling Between Synthetic Cells [PDF]
Small ScienceCell signaling through direct physical cell–cell contacts plays vital roles in biology during development, angiogenesis, and immune response. Intercellular communication mechanisms between synthetic cells constructed from the bottom up are majorly ...
Hossein Moghimianavval +4 more
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On biochemical constructors and synthetic cells. [PDF]
Interface Focus, 2023 Is it possible to build life? More specifically, is it possible to create a living synthetic cell from inanimate building blocks? This question precipitated into one of the most significant grand challenges in biochemistry and synthetic biology, with several large research consortia forming around this endeavour in Europe (European Synthetic Cell ...
Maerkl SJ.
europepmc +3 more sources
Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells [PDF]
Advanced ScienceNatural killer (NK) cells are critical components of the first‐line immune defense, responsible for eliminating tumorigenic cells. NK cell‐based adoptive immunotherapy has gained increasing attention; however, cryopreservation, a standard technique for ...
Xiangda Zhou +20 more
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