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On the “Life-Likeness” of Synthetic Cells [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
One of the most exciting and rapidly expanding research area incontemporary science isthe bottom-up construction of artificial cell-like systems, also known as synthetic cells. Suchapproaches are part of the synthetic biology research paradigm, which equates to understandingmeans constructing. Accordingly, these artificial systemsare considered able to
Luisa Damiano, Pasquale Stano
doaj   +5 more sources

Division in synthetic cells

Chemical Society Reviews, 2023
In this review, we summarize the strategies of inducing division in synthetic cells by using physical, chemical, and biological stimuli, and highlight the future challenges to the construction of autonomous synthetic cell division.
Mu-Yueh Chang, Hirotaka Ariyama, Wilhelm T. S. Huck, Nan-Nan Deng   +3 more
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Morphogenesis in Synthetic Chemical Cells [PDF]

The Journal of Physical Chemistry Letters, 2022
We present an efficient model for describing morphogenesis and the emergence of spatiotemporal structures in synthetic chemical cells. This work is motivated by an experimental setup used for testing Turing's theory of morphogenesis. The model developed is based on the general theory of chemically active droplets, which combines the classical theory of
Leonardo Silva-Dias, Alejandro Lopez-Castillo   +1 more
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A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells [PDF]

, 2013
Growth and differentiation of multicellular systems is orchestrated by spatially restricted gene expression programs in specialized subpopulations. The targeted manipulation of such processes by synthetic tools with high-spatiotemporal resolution could ...
Metzger, Stéphanie, Busacker, Moritz, Engesser, Raphael, Kämpf, Michael M., Nagy, Ferenc István, Müller, Konrad   +5 more
core   +3 more sources

LSB2/Synthetic-neuromorphic-computing-in-living-cells-_2022:

, 2022
@Synthetic neuromorphic computing in living ...
LSB2
core   +1 more source

Gene-Expressing Liposomes as Synthetic Cells for Molecular Communication Studies

Frontiers in Bioengineering and Biotechnology, 2019
The bottom-up branch of synthetic biology includes—among others—innovative studies that combine cell-free protein synthesis with liposome technology to generate cell-like systems of minimal complexity, often referred to as synthetic cells.
Giordano Rampioni, Francesca D'Angelo, Livia Leoni, Pasquale Stano   +3 more
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Synthetic Cell as a Platform for Understanding Membrane-Membrane Interactions

Membranes, 2021
In the pursuit of understanding life, model membranes made of phospholipids were envisaged decades ago as a platform for the bottom-up study of biological processes.
Bineet Sharma, Hossein Moghimianavval, Sung-Won Hwang, Allen P. Liu   +3 more
doaj   +1 more source

Uptake of synthetic low density lipoprotein by leukemic stem cells — a potential stem cell targeted drug delivery strategy [PDF]

, 2010
Chronic Myeloid Leukemia (CML) stem/progenitor cells, which over-express Bcr-Abl, respond to imatinib by a reversible block in proliferation without significant apoptosis.
Jørgensen, Heather G., Jorgensen, Heather G., Tessa L. Holyoake, Heather G. Jørgensen, Elliott, Moira A., Scobie, Linda, Crossan, Claire, Hatziieremia, Sophia, Zhou, Peixun; id_orcid, Elliott, Moira A, Sophia Hatziieremia, Michie, Alison M, Holyoake, Tessa L., Holyoake, Tessa L, Jørgensen, Heather G, Alison M. Michie, Halbert, Gavin W., Linda Scobie, Gavin W. Halbert, Moira A. Elliott, Claire Crossan, Michie, Alison M., Peixun Zhou, Halbert, Gavin W, Zhou, Peixun   +24 more
core   +1 more source

T7Max transcription system

Journal of Biological Engineering, 2023
Background Efficient cell-free protein expression from linear DNA templates has remained a challenge primarily due to template degradation. In addition, the yields of transcription in cell-free systems lag behind transcriptional efficiency of live cells.
Christopher Deich, Brock Cash, Wakana Sato, Judee Sharon, Lauren Aufdembrink, Nathaniel J. Gaut, Joseph Heili, Kaitlin Stokes, Aaron E. Engelhart, Katarzyna P. Adamala   +9 more
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Towards a synthetic cell cycle [PDF]

Nature Communications, 2021
AbstractRecent developments in synthetic biology may bring the bottom-up generation of a synthetic cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which DNA replication and segregation as well as cell growth and division are well integrated. Here, we describe different approaches to recreate these processes in
Lorenzo Olivi, Mareike Berger, Ramon N. P. Creyghton, Nicola De Franceschi, Cees Dekker, Bela M. Mulder, Nico J. Claassens, Pieter Rein ten Wolde, John van der Oost   +8 more
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