Microfluidics for Artificial Life: Techniques for Bottom-Up Synthetic Biology [PDF]
Micromachines, 2019 Synthetic biology is a rapidly growing multidisciplinary branch of science that exploits the advancement of molecular and cellular biology. Conventional modification of pre-existing cells is referred to as the top-down approach.
Pashiini Supramaniam +2 more
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Organizational change of synthetic biology research: Emerging initiatives advancing a bottom-up approach [PDF]
Current Research in BiotechnologyBottom-up Synthetic Biology (buSynBio) is an approach focused on the artificial making of minimal functional biosynthetic systems by recombining existent biochemical modules or manufacturing them from scratch.
Renan Gonçalves Leonel da Silva +5 more
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Social and ethical checkpoints for bottom-up synthetic biology, or protocells. [PDF]
Syst Synth Biol, 2009 An alternative to creating novel organisms through the traditional "top-down" approach to synthetic biology involves creating them from the "bottom up" by assembling them from non-living components; the products of this approach are called "protocells ...
Bedau MA +3 more
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Challenges in observing transcription–translation for bottom-up synthetic biology [PDF]
QRB DiscoverySynthetic biology aims to create a viable synthetic cell. However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and ...
Vadim G. Bogatyr, Gijs J. L. Wuite
doaj +6 more sources
Bottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis [PDF]
Microbial Cell Factories, 2022 Background Menaquinone-7 (MK-7), which is associated with complex and tightly regulated pathways and redox imbalances, is produced at low titres in Bacillus subtilis.
Xiumin Ding +8 more
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Bottom-up assembly of viral replication cycles [PDF]
Nature Communications, 2022 Synthetic biology encompasses engineering approaches to either redesign biological organisms with new molecular abilities or build up organism from the bottom to improve our understanding of life.
Oskar Staufer +5 more
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Rapid Multi-Well Evaluation of Assorted Materials for Hydrogel-Assisted Giant Unilamellar Vesicle Production: Empowering Bottom-Up Synthetic Biology [PDF]
GelsGiant unilamellar vesicles (GUVs) are versatile cell models in biomedical and environmental research. Of the various GUV production methods, hydrogel-assisted GUV production is most easily implemented in a typical biological laboratory. To date, agarose,
Cherng-Wen Darren Tan +2 more
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Automated synthetic cell-based screening for designed proteins with emergent functions [PDF]
Nature CommunicationsDesigning minimal biological systems with emergent functions such as spatiotemporal self-organization is a central goal of bottom-up synthetic biology.
Kareem Al Nahas +4 more
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Bioinspired Networks of Communicating Synthetic Protocells
Frontiers in Molecular Biosciences, 2021 The bottom-up synthesis of cell-like entities or protocells from inanimate molecules and materials is one of the grand challenges of our time. In the past decade, researchers in the emerging field of bottom-up synthetic biology have developed different ...
Patrick J. Grimes +4 more
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Synthetic bio/techno/logy and its application
Biotechnology & Biotechnological Equipment, 2021 Synthetic Biology, which began in the 1970s, is a rapidly growing, multidisciplinary field that aims at improving our capacity to design, assemble or develop biological molecules.
Alemu Tebeje +2 more
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