Results 31 to 40 of about 11,682,231 (209)
Advanced Science, 2022 Extracellular vesicles (EVs) are fundamental for proper physiological functioning of multicellular organisms. By shuttling nucleic acids and proteins between cells, EVs regulate a plethora of cellular processes, especially those involved in immune ...
Oskar Staufer +5 more
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In vitro assembly, positioning and contraction of a division ring in minimal cells
Nature Communications, 2022 Constructing a minimal protein machinery for self-division of membrane compartments is a major goal of bottom-up synthetic biology. Here, authors achieved the assembly, placement and onset of contraction of a minimal division ring in lipid vesicles.
Shunshi Kohyama +2 more
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Symmetry Breaking and Emergence of Directional Flows in Minimal Actomyosin Cortices
Cells, 2020 Cortical actomyosin flows, among other mechanisms, scale up spontaneous symmetry breaking and thus play pivotal roles in cell differentiation, division, and motility.
Sven K. Vogel +5 more
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Sensing intracellular signatures with synthetic mRNAs
RNA Biology, 2023 The bottom-up assembly of biological components in synthetic biology has contributed to a better understanding of natural phenomena and the development of new technologies for practical applications.
Hiroki Ono, Hirohide Saito
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Engineering tRNA abundances for synthetic cellular systems
Nature Communications, 2023 Routinizing the engineering of synthetic cells requires specifying beforehand how many of each molecule are needed. Physics-based tools for estimating desired molecular abundances in whole-cell synthetic biology are missing.
Akshay J. Maheshwari +3 more
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A Synthetic Post-transcriptional Controller To Explore the Modular Design of Gene Circuits [PDF]
, 2012 The assembly from modular parts is an efficient approach for creating new devices in Synthetic Biology. In the “bottom-up” designing strategy, modular parts are characterized in advance, and then mathematical modeling is used to predict the outcome of ...
Ceroni, Francesca +10 more
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Are the biomedical sciences ready for synthetic biology?
Biomolecular Concepts, 2020 The ability to construct a functional system from its individual components is foundational to understanding how it works. Synthetic biology is a broad field that draws from principles of engineering and computer science to create new biological systems ...
DeNies Maxwell S. +2 more
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Pictures of Synthetic Biology [PDF]
, 2009 This article is concerned with the representation of Synthetic Biology in the media and by biotechnology experts. An analysis was made of German-language media articles published between 2004 and 2008, and interviews with biotechnology-experts at the ...
Seiringer, Alexandra +3 more
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Cell‐free synthetic biology: a bottom‐up approach to discovery by design [PDF]
Molecular Systems Biology, 2006 The practitioners of the brand of synthetic biology that lies closest to engineering are fond of quoting the phrase Richard Feynman had written on his blackboard: ‘What I cannot create I do not understand’. This phrase captures both a warning about the limitations of analysis in understanding complex systems and an endorsement of the value of design in
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A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology [PDF]
Nucleic Acids Research, 2014 Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly adopted strategy is to fit data to Hill-shaped curves without considering the underlying molecular mechanisms.
M. Carbonell-Ballestero +5 more
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