Results 51 to 60 of about 11,682,231 (209)

GeoV: An Open‐Source Software Package for Quantitative Image Analysis of 3D Vesicle Morphologies

Advanced Intelligent Systems, 2023
Bottom‐up synthetic biology has reconstituted processes like adhesion, cortex formation, or division of giant lipid vesicles (GUVs), which all rely on changes in the vesicle morphology.
Yannik Dreher, Jakob Niessner, Andreas Fink, Kerstin Göpfrich   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Two Possible AI-Related Paths for Bottom-Up Synthetic Cell Research

, 2022
Advancements in bottom-up synthetic biology (i.e., constructing synthetic cells from scratch) pave the way to new and yet unexplored directions, like: (i) the exploration of semantic aspects of chemical information processing, and (ii) the potential ...
Stano, Pasquale, Pasquale Stano
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?

Molecules, 2023
The potential role of bottom-up Synthetic Cells (SCs) in the Internet of Bio-Nano Things (IoBNT) is discussed. In particular, this perspective paper focuses on the growing interest in networks of biological and/or artificial objects at the micro- and ...
Pasquale Stano, Pier Luigi Gentili, Luisa Damiano, Maurizio Magarini   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Building synthetic multicellular systems using bottom–up approaches

, 2020
A grand challenge in bottom–up synthetic biology is the designand construction of synthetic multicellular systems usingnonliving molecular components. Abstracting key features ofcompartmentalisation, reaction and diffusion, and communica-tion provides ...
Tang, T., Gonzales, D., Zechner, C., Zechner, C, Tang, TYD, Gonzales, DT, T.-Y. Dora Tang, David T. Gonzales, Christoph Zechner   +8 more
core   +1 more source

Addressing Emerging Synthetic Biology Threats: The Role of Education and Outreach in Fostering Effective Bottom-Up Grassroots Governance [PDF]

, 2021
AbstractThis chapter seeks to examine the role of the synthetic biology community in strengthening biosafety and biosecurity and safeguarding synthetic biology against accidental and deliberate misuse. It argues that biosafety and biosecurity education, awareness-raising, and outreach are essential for fostering effective bottom-up (self-governance ...
Tatyana Novossiolova, Todd Kuiken, Jared DeCoste, Luc Henry, Ineke Malsch, Myriam Merad, Carl Newman, Wallace Patterson, Alexandra Waskow   +8 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cell-Free Protein Expression by a Reconstituted Transcription–Translation System Energized by Sugar Catabolism

Molecules
Cooperation between catabolism and anabolism is crucial for maintaining homeostasis in living cells. The most fundamental systems for catabolism and anabolism are the glycolysis of sugars and the transcription–translation (TX-TL) of DNA, respectively ...
Gaku Sato, Shintaro Miyazawa, Nobuhide Doi, Kei Fujiwara   +3 more
doaj   +1 more source