Amyloid assemblies: Protein legos at a crossroads in bottom-up synthetic biology
ChemBioChem, 2010 11 páginas, 4 figuras, 1 esquema -- PAGS nros. 2347-2357One of the major objectives that bottom-up synthetic biology shares with chemical biology is to engineer extant biological molecules to implement novel functionalities in living systems.
Giraldo, R., Rafael Giraldo
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Is Research on “Synthetic Cells” Moving to the Next Level?
Life, 2018 “Synthetic cells” research focuses on the construction of cell-like models by using solute-filled artificial microcompartments with a biomimetic structure. In recent years this bottom-up synthetic biology area has considerably progressed, and
Pasquale Stano
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Smart nucleic acid condensates for bottom-up synthetic biology
, 2023 Bottom-up synthetic biology aims at rationally engineering life-like behaviours, such as gene expression, energy production and communication, in synthetic entities assembled from bio-active components, termed artificial cells.
Fabrini, Giacomo
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Origin of life from a maker's perspective -- focus on protocellular compartments in bottom-up synthetic biology [PDF]
CoRR, 2022 The origin of life is shrouded in mystery, with few surviving clues, obscured by evolutionary competition. Previous reviews have touched on the complementary approaches of top-down and bottom-up synthetic biology to augment our understanding of living ...
Nourafkan, Ehsan +4 more
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Bottom-up synthetic biology: reconstitution in space and time
Current Opinion in Biotechnology, 2019 Bottom-up reconstituting well-characterized functional molecular entities, parts and modules towards a synthetic cell will give new insights into the mechanisms and origin of life.
Schwille, P., Jia, H.
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The rise of bottom-up synthetic biology and cell-free biology. [PDF]
Phys Biol, 2019 Liu AP.
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Nanofluidics for Pioneering Synthetic Biology of Bottom-Up Cell-Free Molecular Systems. [PDF]
ACS Synth BiolAbstract Synthetic biology via bottom-up assembly is transitioning from stochastic, extract-based cell-free systems toward reconstituted, molecularly defined cell-free molecular systems. Transitioning to molecularly defined systems provides a path to quantitative design; however, the active assembly of these molecular building blocks ...
Wu S, Ma Q, Takai M, Xu Y.
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Membrane-coated 3D architectures for bottom-up synthetic biology
Soft Matter, 2021 This paper outlines a robust method to template biological membranes in 3D geometries using micron-scale 3D printing. Dynamic protein systems were reconstituted in vitro and their self-organization was observed in response to the 3D geometry.
Hiromune Eto +3 more
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Bottom-Up Synthetic Biology for Artificial Cell Design: From Scaffold Materials to Functional Integration. [PDF]
J Microbiol BiotechnolCells are extraordinary biochemical systems that have evolved over billions of years into highly sophisticated units of life. Bottom-up synthetic biology seeks to reconstruct cell-like systems from non-living molecular components, producing artificial cells that capture essential cellular features while bypassing the complexity and fragility of living ...
Park SH, Jo SM.
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Chemical synthetic biology [PDF]
, 2021 Synthetic biology, which in 2020 turned 20 years old, is a very dynamically developing field. Unlike traditional molecular and cellular biology, synthetic biology focuses on the design and construction of parts, devices and systems such as enzymes ...
Huszcza, Ewa, Ewa Huszcza
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