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The bioethics of synthetic cells [PDF]
Nature Reviews Molecular Cell Biology, 2023 The Building a Synthetic Cell (BaSyC) consortium — launched in 2017 — proposes to create “an autonomous self-reproducing cell that can sustain itself, replicate and divide”. I joined this consortium to explore the bioethics of creating synthetic cells, by embedding philosophical reflection into research practices.
Zwart, Hub; id_orcid
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Controlling Synthetic Cell-Cell Communication [PDF]
Frontiers in Molecular Biosciences, 2022 Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide application, for instance in studying cellular communication and as delivery devices to living cells. However, to fully realise the potential of synthetic cells,
Jefferson M. Smith +2 more
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Synthetic multistability in mammalian cells [PDF]
Science, 2021 Abstract In multicellular organisms, gene regulatory circuits generate thousands of molecularly distinct, mitotically heritable states, through the property of multistability. Designing synthetic multistable circuits would provide insight into natural cell fate control circuit architectures and allow engineering of multicellular ...
Ronghui Zhu +3 more
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Interfacing Synthetic Cells with Biological Cells: An Application of the Synthetic Method
The 2018 Conference on Artificial Life, 2018 The “synthetic method” is the methodological approach that guides current scientific attempts of understanding natural processes by the construction of hardware, software, and/or wetware models fro...
Rampioni, G. +4 more
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Is Research on “Synthetic Cells” Moving to the Next Level?
Life, 2018 “Synthetic cells” research focuses on the construction of cell-like models by using solute-filled artificial microcompartments with a biomimetic structure. In recent years this bottom-up synthetic biology area has considerably progressed, and
Pasquale Stano
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Reprogramming cells with synthetic proteins
Asian Journal of Andrology, 2015 Conversion of one cell type into another cell type by forcibly expressing specific cocktails of transcription factors (TFs) has demonstrated that cell fates are not fixed and that cellular differentiation can be a two-way street with many intersections ...
Xiaoxiao Yang, Vikas Malik, Ralf Jauch
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Synthetic cells in tissue engineering [PDF]
Current Opinion in BiotechnologyTissue functions rely on complex structural, biochemical, and biomechanical cues that guide cellular behavior and organization. Synthetic cells, a promising new class of biomaterials, hold significant potential for mimicking these tissue properties using simplified, nonliving building blocks. Advanced synthetic cell models have already shown utility in
Anna Burgstaller +2 more
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Influence of synthetic superparamagnetic iron oxide on dendritic cells [PDF]
International Journal of Nanomedicine, 2011 Yongbin Mou1, Baoan Chen2, Yu Zhang3, Yayi Hou4, Hao Xie4, Guohua Xia2, Meng Tang5, Xiaofeng Huang1, Yanhong Ni1, Qingang Hu1,6 1Central Laboratory of Stomatology, Stomatological Hospital Affiliated Medical School, Nanjing University, 2Department of ...
Ni Y +9 more
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From primal scenes to synthetic cells [PDF]
eLife, 2019 Synthetic cells spark intriguing questions about the nature of life. Projects such as BaSyC (Building a Synthetic Cell) aim to build an entity that mimics how living cells work. But what kind of entity would a synthetic cell really be?
Hub Zwart
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In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide
International Journal of Nanomedicine, 2011 Yongbin Mou1, Yayi Hou2, Baoan Chen3, Zichun Hua4, Yu Zhang5, Hao Xie2, Guohua Xia3, Zhiyong Wang1, Xiaofeng Huang1, Wei Han1, Yanhong Ni1, Qingang Hu1,6 1Central Laboratory of Stomatology, Stomatological Hospital Affiliated Medical School, Nanjing ...
Hu QG +11 more
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