Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
The Dark Side of Light: A Transdisciplinary Research Agenda for Light Pollution Policy
Although the invention and widespread use of artificial light is clearly one of the most important human technological advances, the transformation of nightscapes is increasingly recognized as having adverse effects.
Franz Hölker +15 more
doaj +1 more source
Vibronic origin of long-lived coherence in an artificial molecular light harvester
Natural and artificial light harvesting processes have recently gained new interest. Signatures of long lasting coherence in spectroscopic signals of biological systems have been repeatedly observed, albeit their origin is a matter of ongoing debate, as ...
Caycedo-Soler, Felipe +9 more
core +1 more source
Measures of Light in Studies on Light-Driven Plant Plasticity in Artificial Environments [PDF]
Within-canopy variation in light results in profound canopy profiles in foliage structural, chemical, and physiological traits. Studies on within-canopy variations in key foliage traits are often conducted in artificial environments, including growth ...
Keenan, Trevor, Niinemets, Ülo
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Evaluation of lighting conditions in portable classrooms and analysis for alternative daylighting systems [PDF]
Lighting conditions in multiple classrooms in central Texas were assessed, and the feasibility of improving portable classroom daylighting via alternative daylighting systems was also evaluated.
Zhang, Yan, M.S. in Engineering
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Large mass expansion in two-loop QCD corrections of para-charmonium decay
We calculate the two-loop QCD corrections to paracharmonium decays $eta_{c} rightarrow gamma gamma$ and $eta_{c} rightarrow g g$ involving light-by-light scattering diagrams with light quark loops.
Alexey Pak, F. V. Tkachov, K. Hasegawa
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source

