Results 21 to 30 of about 192,160 (247)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Design, analysis, and control of a cable-driven parallel platform with a pneumatic muscle active support [PDF]

open access: yes, 2017
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Qian, Lu, Zhao, Xingwei, Zi, Bin
core   +1 more source

The design, kinematics and torque analysis of the self-bending soft contraction actuator [PDF]

open access: yes, 2020
This article presents the development of a self-bending contraction actuator (SBCA) through analysis of its structure, kinematics, and torque formulas, and then explores its applications.
Al-Ibadi, A, Davis, ST, Nefti-Meziani, S
core   +2 more sources

Stiffness Graded Electroactive Artificial Muscle

open access: yesAdvanced Functional Materials, 2022
AbstractIn nature, hydrostatic, endo‐ and exo‐skeletons are widely observed, and provide essential rigidity and anchoring points for the application of muscular forces. The efficient interface between a hard skeleton and soft muscle in biology is made possible by a complex hierarchy of structures and composite materials, extending from the nano‐ to the
Majid Taghavi   +3 more
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

On Neuromechanical Approaches for the Study of Biological Grasp and Manipulation

open access: yes, 2017
Biological and robotic grasp and manipulation are undeniably similar at the level of mechanical task performance. However, their underlying fundamental biological vs.
Santello, Marco   +1 more
core   +1 more source

Muscle synergies in neuroscience and robotics: from input-space to task-space perspectives [PDF]

open access: yes, 2013
In this paper we review the works related to muscle synergies that have been carried-out in neuroscience and control engineering. In particular, we refer to the hypothesis that the central nervous system (CNS) generates desired muscle contractions by ...
Bastien eBerret   +7 more
core   +4 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A novel design process of low cost 3D printed ambidextrous finger designed for an ambidextrous robotic hand [PDF]

open access: yes, 2015
This paper presents the novel mechanical design of an ambidextrous finger specifically designed for an ambidextrous anthropomorphic robotic hand actuated by pneumatic artificial muscles.
Akyürek, E   +9 more
core  

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