Results 31 to 40 of about 78,149 (267)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Impact of pregnancy and nutrition on oxidant⁄antioxidant balance in sheep and goats reared in South Sinai, Egypt [PDF]

Veterinary World, 2016
Aim: To monitor the effect of nutrition and pregnancy on oxidative status of animals under the arid condition of South Sinai. Materials and Methods: Blood samples were taken from two groups of animals: The first group retained in farm and fed on ...
M. F. Nawito, Amal R. Abd El Hameed, A. S. A. Sosa, Karima Gh. M. Mahmoud   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Optimizing Cryopreservation: The Effect of MitoTEMPO and Glycerol Ratios on Ram Semen Quality After Freezing and Thawing

Veterinary Medicine and Science
Background MitoTEMPO is an important mitochondrial targeted and ROS scavenging antioxidant. It is often used as antiviral, anticancer and immunomodulator agents.
Recep Hakkı Koca, İbrahim Halil Güngör, Aslıhan Çakır Cihangiroğlu, Tutku Can Acısu, Nida Badıllı, Serkan Ali Akarsu, Şeyma Özer Kaya, Emre Kaya, Gaffari Türk, Mustafa Sönmez, Seyfettin Gür   +10 more
doaj   +1 more source

Effects of Platelet-Rich Plasma Dose and Application Strategy on Post-Thaw Spermatological Parameters in Goat Semen

Veterinary Sciences
This study investigated the effects of different PRP doses and application strategies on sperm quality in goats during cryopreservation. Semen samples were collected weekly from six Boer goats and treated with PRP either by means of pre-incubation or ...
Ahmet Eser, Kemal Bağcı, Abdurrahman Alakuş, Aslıhan Çakır Cihangiroğlu, İkra Karaağaç, Selin Yağcıoğlu, Ramazan Arıcı, Kamber Demir   +7 more
doaj   +1 more source

Cryoprotective and antioxidant effects of maca (lepidium meyenii) supplementation on post-thaw quality of ram sperm [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
The aim of this study was to evaluate the effects of Maca (Lepidium meyenii) supplementation on the freezing process of ram semen. Semen samples were collected from Tuj breed rams using an electroejaculator method and subsequently pooled and divided into
Taygun GÖKDEMİR, Nail Tekin ÖNDER, Muhammet Can KILIÇ, Oğuzhan ŞAHİN, Lale BAŞER, Yavuz ÖZTÜRKLER, Savaş YILDIZ   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Precursor A-Kinase Anchor Protein 4 as a Predictive Biomarker of Post-Thaw Semen Quality in Goats

Veterinary Sciences
The evaluation of sperm proteins has emerged as a promising approach to predicting semen quality across animal species. This study investigated the relationship between post-thaw concentrations of precursor A-kinase anchor protein 4 (proAKAP4) and ...
Ahmet Eser, Abdurrahman Alakuş, Kemal Bağcı, Aslıhan Çakır Cihangiroğlu, Selin Yağcıoğlu, Ramazan Arıcı, Kamber Demir   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source