Results 221 to 230 of about 1,485,663 (260)

An Artificial Imine Reductase based on the Ribonuclease S Scaffold

ChemCatChem, 2014
AbstractDative anchoring of a piano‐stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S‐peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values ...
Thomas R Ward, Ralf Hoffmann, Norbert Sträter   +2 more
exaly   +2 more sources

SYNTHESIS AND CHARACTERIZATION OF POLYAMINE-BASED BIOMIMETIC CATALYSTS AS ARTIFICIAL RIBONUCLEASE

Nucleosides, Nucleotides and Nucleic Acids, 2001
Several polyamine derivatives (I-V) conjugated with or without an intercalative moiety were prepared as ribonuclease mimics. Although no DNA-cleaving activity was observed for all compounds tested, mimics I, III, and V bearing an intercalative moiety along with the primary amine and/or imidazole moieties exhibited potent RNA-cleaving activity at near ...
Hiroaki Sawai, Kazuo Shinozuka, H Sawai   +2 more
exaly   +3 more sources

The Sequence-Specific Cleavage of RNA by Artificial Chemical Ribonucleases

Antisense and Nucleic Acid Drug Development, 1997
Based on work spanning 50 years, several groups have recently achieved the specific cleavage of RNA by attaching RNA-cleaving chemical moieties to antisense oligonucleotides. Such artificial chemical ribonucleases have potential as a possible next generation of antisense compounds and also as probes for structural and functional investigations of RNA ...
R, Häner, J, Hall
openaire   +2 more sources

Molecular Design of Artificial Ribonucleases Using Electrostatic Interaction

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ekaterina A, Burakova, Vladimir N, Silnikov   +1 more
openaire   +2 more sources

Oligonucleotides containing abasic threoninol-terpyridine residues as potential artificial ribonucleases

Journal of Inorganic Biochemistry, 2022
Artificial ribonucleases, also known as synthetic ribozymes, were synthesized with an internal, stereochemically-pure, abasic threoninol backbone-residue to which the RNA transesterification catalyst copper (II) terpyridine was covalently linked.
William C, Putnam, James K, Bashkin
openaire   +2 more sources

ChemInform Abstract: A Method for Synthesis of an Artificial Ribonuclease

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hans Aastroem, Roger Stroemberg
openaire   +1 more source

SPEED LIMITS FOR ARTIFICIAL RIBONUCLEASES

Comments on Inorganic Chemistry, 2008
There are four major catalytic roles for natural and artificial nucleases that catalyze the hydrolytic cleavage of RNA. For metal ion complexes that act as artificial nucleases, the most important role is the stabilization of the phosphorane-like transition state.
openaire   +1 more source

Characterization of an artificial dimer of ribonuclease H using 1H NMR spectroscopy

Journal of Biomolecular NMR, 1996
The protein fusion technique was applied in the synthesis of an artificial dimer of ribonuclease H (305 residues). 1H NMR spectroscopy was used to analyze the structure of this dimer. Spectral profiles and pKa values of the histidine residues obtained using 1H NMR indicate that the dimer retains the secondary and tertiary structures of the intact ...
S Kanaya
exaly   +3 more sources

Allosterically Controlled Ribozymes as Artificial Ribonucleases

2004
Ribozymes are catalytic RNAs. Representative ribozymes that exist in nature include hammerhead, hairpin, hepatitis delta virus (HDV) and Neurospora VS ribozymes; group I and II introns; the RNA subunit of RNase P; and ribosomal RNA (Birikh et al. 1997; Doudna 1998; Zhou and Taira 1998; Walter and Burke 1998; Carola and Eckstein 1999; Gesteland et al ...
M. Iyo, H. Kawasaki, M. Miyagishi, K. Taira   +3 more
openaire   +1 more source

An RNA sequence determines the speed of its cleavage by artificial ribonucleases

Russian Journal of Bioorganic Chemistry, 2010
Phosphodiester bonds in RNA situated between similar nucleotides but in different sequences (context) were split under the action of artificial and natural ribonucleases with different speeds, and the reason for this phenomenon has not yet been fully revealed.
N V, Tamkovich, A N, Zenkov, V V, Vlasov, M A, Zenkova   +3 more
openaire   +2 more sources