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Antiviral Research, 2016 Artificial ribonucleases (aRNases) are small compounds catalysing RNA cleavage. Recently we demonstrated that aRNases readily inactivate various viruses in vitro. Here, for three series of aRNases (1,4-diazabicyclo [2.2.2]octane-based and peptide-like compounds) we show that apart from ribonuclease activity the aRNases display chaotropic-like and ...
Sameen Yousaf +2 more
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Anticancer Activity of Reconstituted Ribonuclease S‐Decorated Artificial Viral Capsid
ChemBioChem, 2022 AbstractRibonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S‐decorated artificial viral capsids with a size of 70–170 nm by self‐assembly of the β‐annulus‐S‐peptide followed by ...
Kazunori Matsuura +2 more
exaly +3 more sources
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A METHOD FOR SYNTHESIS OF AN ARTIFICIAL RIBONUCLEASE
Nucleosides, Nucleotides and Nucleic Acids, 20015-Amino-2,9-dimethyl-1,10-phenanthroline-oligonucleotide conjugates have been synthesized. A 2'-O-methyl octaribonucleotide carrying a 2'-aminoethoxymethyl linker in a central position was produced. Reaction of the aminoneocuproine phenyl carbamate with the fully deprotected oligonucleotide in aqueous solution gave virtually quantitative conversion ...
Roger Strömberg
exaly +3 more sources
Org. Biomol. Chem., 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Teija, Niittymäki, Harri, Lönnberg
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Teija, Niittymäki, Harri, Lönnberg
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Journal of Molecular Biology, 1996 We describe the mechanism of ribonuclease inhibition by ribonuclease inhibitor, a protein built of leucine-rich repeats, based on the crystal structure of the complex between the inhibitor and ribonuclease A.
Boštjan Kobe, Johann Deisenhofer
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Synthesis and Characterization of Artificial Ribonucleases
Nucleosides and Nucleotides, 1999Abstract RNA cleaving molecules were synthesized by conjugating components of ribonucleases A and T1 catalytic centers (imidazole, aliphatic amino and/or carboxy residues) to intercalating and cationic structures. The artificial ribonucleases were shown cleave RNA at Py-Pu sites in single-stranded regions.
Zhdan, N. S. +6 more
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Combinatorial Library of Artificial Ribonucleases
Nucleosides and Nucleotides, 1999Abstract Conjugates of lanthanide complexes and oligonucleotides have been shown to bind and to cleave complementary RNA. Modified oligonucleotide building blocks are required to ensure stability of the oligonucleotide against cellular nucleases. For an efficient cleavage, an accessible site on the structured mRNA is required. For the identification of
Dieter Hüsken +3 more
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Design and Synthesis of Metal-Free Artificial Ribonucleases
Protein & Peptide Letters, 2007The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.
Ludmila S, Koroleva +3 more
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