Results 51 to 60 of about 7,439 (222)

Design and synthesis of dinuclear bismuth(III) complexes with potent ribonuclease-like activity

Several metal complexes with ribonuclease-like activity have been developed as chemical biology tools for RNA regulation. However, their RNA-cleavage activity is insufficient under physiological conditions.
Yasunobu, Yamashita, Yutaro, Hanatani, Yukihiro, Itoh, Sacha, Marynberg, Takayoshi, Suzuki, Takashi, Kurohara, Yuri, Takada   +6 more
core   +1 more source

Utilização de macromoléculas contendo o grupo funcional ácido hidroxâmico como modelos miméticos na clivagem de ésteres de fosfato e acetato: avaliando o efeito da cooperatividade entre grupos funcionais [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2010Um polímero contendo os grupos funcionais ácido hidroxâmico e ácido carboxílico foi preparado ...
Mello, Renata da Silva
core  

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Molecular surface of several proteins (middle panel) and several artificial nano-surfaces and objects.

, 2013
The amphiphilic (blue – hydrophilic; red - hydrophobic) molecular surface is mapped at 1.4 Å (water molecule dimensions) geometrical resolution, for five proteins, from left to right and top to bottom: lysozyme, ribonuclease; hemoglobin; IgG and albumin.
Ewa Paszek (390042), Florin Fulga (390043), Dan V. Nicolau Jr (321634), Dan V. Nicolau (390041)   +3 more
core   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Cyclen-based lanthanide complexes as ribonuclease mimics

, 2004
THESIS 7479This thesis, entitled "Novel Cyclen-based Lanthanide Complexes as Ribonuclease Mimics" is divided into six chapters. Chapter One introduces the field of mRNA cleavage, with emphasis on the hydrolysis of phosphodiesters.
Mulready, Sinead
core  

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Funcionalização combinatorial da polietilenoimina e caracterização cinético evolucionária como modelo de planejamento de enzinas artificiais [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Numerosas tentativas têm sido feitas para preparar polímeros sintéticos mimetizando enzimas.
Ricardo, Juan
core  

Tumor‐Mimic Artificial Cell Integrated With In Situ Synthetic Biology for Testing of Antitumor Drug Sensitivity

Exploration, EarlyView.
A biomimetic artificial cell model platform integrating in situ synthetic biology is developed, which can show antitumor drug response to simulated cells derived from cell membranes of different tumor cells. It has excellent performance in indicating the curative effect of drugs at the cellular level and provides a novel approach for enhancing the ...
Chaoyang Guan, Runchi Zhang, Zhihui Zhou, Pei Sun, Yichun Mao, Changqing Mao, Yonggeng Ma, Guifang Chen, Qiuhong Man, Chang Feng   +9 more
wiley   +1 more source