Results 71 to 80 of about 1,576,930 (245)
Advanced Science, EarlyView.Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu +9 more
wiley +1 more source
The action of ribonuclease in coacervates
, 2019 The study of ribonuclease activity within coacervate ...
Oparin A.I. (7209727) +1 more
core +1 more source
Advanced Science, EarlyView.A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang +10 more
wiley +1 more source
ANG (angiogenin, ribonuclease, RNase A family, 5) [PDF]
, 2011 Review on ANG (angiogenin, ribonuclease, RNase A family, 5), with data on DNA, on the protein encoded, and where the gene is ...
S Shimoyama, Shimoyama, S
core +1 more source
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
, 1966 1. The presence of two RNA-degrading enzymes, one with optimum activity at pH 5·6 (acid ribonuclease) and the other with optimum activity at pH 7·8 (alkaline ribonuclease), in rat adrenals has been demonstrated.
Girija, N. S., Sreenivasan, A.
core +1 more source
Advanced Science, EarlyView.Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou +11 more
wiley +1 more source
Cytotoxicity of Polyspermine-Ribonuclease A and Polyspermine-Dimeric Ribonuclease A
, 2007 Polyspermine-ribonuclease A (PS-RNase A) and polyspermine-dimeric ribonuclease A (PS-dimeric RNase A) were prepared by cross-linking ribonuclease A or its covalently linked dimer to polyspermine (PS) using dimethyl suberimidate.
M. MORBIO +9 more
core +1 more source
, 1976 Endonucleolytic mechanism of degradation of double-helix RNA by ribonuclease BS-1 and by ribonuclease A ...
PALMIERI, Marta, LIBONATI, Massimo
core +1 more source
Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens
Advanced Science, EarlyView.Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu +12 more
wiley +1 more source