Results 81 to 90 of about 7,439 (222)
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Ribonuclease BN: identification and partial characterization of a new tRNA processing enzyme
, 1983 A new ribonuclease, RNase BN, has been identified and partially purified from a strain of Escherichia coli lacking RNase II and RNase D by using the artificial tRNA precursor tRNA-C-[14C]U as substrate. This enzyme is present in E. coli B but absent from
Asha, P K +3 more
core
Substrate recognition and auto-inhibition in the central ribonuclease RNase E. Bandyra et al.
, 2018 Images of electrophoretic gels collected under denaturing conditions for RNA degradation assays recorded with GeneSnap from Syngene. The gels were stained with SybrGold and visualised by uv fluorescence.Figure 1D shows 9S processing by RNase E 1-529 wild
Luisi, B (via Mendeley Data)
core +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak +6 more
wiley +1 more source
Improving the structure of organomercury oligonucleotide conjugates for ribonuclease activity
Artificial ribonucleases are a class of artificial RNA molecules capable of catalysing the cleavage of specific RNA phosphodiester bonds. The discovery and study of artificial ribonuclease have had a major impact on the fields of biology and medicine ...
Yan, Kai
core
Insect Molecular Biology, EarlyView.RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour +8 more
wiley +1 more source
, 2019 : Nowadays, application of miRNases—artificial ribonucleases aimed at degradation of noncoding RNAs, in particular, miRNAs—represents one of the novel experimental approaches to inhibit tumorigenesis.
Patutina, O. A. +5 more
core +1 more source
Evolving treatments for Sjögren disease: current approaches and emerging targets
Internal Medicine Journal, EarlyView.Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani +3 more
wiley +1 more source
Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns
Journal of Integrative Plant Biology, EarlyView.Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng +5 more
wiley +1 more source