Results 261 to 270 of about 408,472 (346)
Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu +16 more
wiley +1 more source
Selbstassemblierte (Aza‐)BODIPY Farbstoffe für Biomedizinische In Vivo Bildgebung
Dieses Minireview klassifiziert (Aza‐)BODIPY‐Farbstoffe anhand ihrer molekularen Stapelungsmodi und Aggregattypen (H‐, oblique‐ oder J‐Typ) in wässrigen Medien und setzt diese Merkmale in Beziehung zu ihrer multimodalen Bildgebungsleistung. Durch die Verknüpfung von molekularem Design, Exzitonenkopplung und pfadabhängiger Assemblierung stellen wir ...
Antonia Albers +2 more
wiley +1 more source
Hydrogen-Mediated Reductive Cross-Coupling of Aryl Iodides with Activated Aryl and Heteroaryl Bromides. [PDF]
Shen W +7 more
europepmc +1 more source
Pyridine Into Pyrrole Transformation Induced Within the Confinement of the Macrocycle
This work demonstrates the nontrivial reactivity of pyridine incorporated into a porphyrin framework. The most significant achievement is the contraction of the six‐membered ring to a pyrrole ring, which is a phenomenon of great interest to researchers in this field.
Paulina Krzyszowska +5 more
wiley +1 more source
Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals. [PDF]
Kuzmin J +3 more
europepmc +1 more source
Synthesis, Structure, and Reactivity of a Magnesium(0) Complex with a Polarized Mgδ−─Caδ+ Bond
Mixing metals: The elusive unsupported two‐center‐two‐electron Mg─Ca bond has been realized by using a combination of β‐diketiminate and amidinate ligands. Due to electronegativity differences (Mg: 1.31, Ca: 1.00) the formal oxidation states are Mg0─CaII.
Sandeep Kumar Thakur +6 more
wiley +1 more source
Widely-used boronic esters as synthetically-versatile directing groups for C-H activation and hydrogen isotope exchange. [PDF]
Townsley JC +6 more
europepmc +1 more source

