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Aryl Hydrocarbon Receptor-Mediated Signal Transduction
Critical Reviews in Toxicology, 1997The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix (bHLH) protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear translocator) forming a complex that binds to xenobiotic regulatory elements in target gene enhancers.
J C, Rowlands, J A, Gustafsson
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Biochemical Pharmacology, 1996
The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes. Northern analysis of poly(A) RNA isolated from splenocytes revealed transcripts of approximately 6.6 kb which hybridized to the AhR ...
C E, Williams +3 more
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The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes. Northern analysis of poly(A) RNA isolated from splenocytes revealed transcripts of approximately 6.6 kb which hybridized to the AhR ...
C E, Williams +3 more
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Auris Nasus Larynx, 2011
The aim of this study was to determine whether aryl hydrocarbon receptor (AhR) and AhR nuclear translocators (ARNTs) are expressed in human adenoid tissue.Paraffin-embedded human adenoid tissue specimens were obtained from eight children with adenoid hypertrophy.
Kazuhiko, Kubo +3 more
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The aim of this study was to determine whether aryl hydrocarbon receptor (AhR) and AhR nuclear translocators (ARNTs) are expressed in human adenoid tissue.Paraffin-embedded human adenoid tissue specimens were obtained from eight children with adenoid hypertrophy.
Kazuhiko, Kubo +3 more
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Aryl hydrocarbon receptors: diversity and evolution
Chemico-Biological Interactions, 2002Animals have evolved inducible enzymatic defenses to facilitate the biotransformation and elimination of toxic compounds encountered in the environment. The sensory component of this system consists of soluble receptors that regulate the expression of certain isoforms of cytochrome P450, other enzymes, and transporters in response to environmental ...
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Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor
Journal of Biochemistry, 2000The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that acts in concert with the AhR nuclear translocator (ARNT), and alters gene expression in response to environmental contaminants such as 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD).
T, Ikuta +5 more
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Trends in Endocrinology & Metabolism, 1994
The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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Mechanistic aspects the dioxin (aryl hydrocarbon) receptor
Food Additives and Contaminants, 2000The Ah receptor mediates the toxicological responses of 2,3,7,8-TCDD and related compounds. Receptor-deficient animals were shown to be resistant to the toxic effects of dioxin, although there is also evidence for the existence of a receptor-independent pathway for dioxin-induced toxicity.
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The aryl hydrocarbon receptor: A comparative perspective
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1998The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor involved in the regulation of several genes, including those for xenobiotic-metabolizing enzymes such as cytochrome P450 1A and 1B forms. Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated ...
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Dexlansoprazole is an aryl hydrocarbon receptor agonist
Food and Chemical ToxicologyDexlansoprazole, a proton pump inhibitor, is commonly used to treat gastro-esophageal reflux disease and erosive esophagitis. The activated aryl hydrocarbon receptor (AhR) functions as a transcription factor by binding to the aryl hydrocarbon response element (AHRE) of its target genes, with cytochrome P450 (CYP) 1A1 being the most well-known target ...
Kuo-Liang Wei +6 more
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Aryl Hydrocarbon Receptor-Interacting Protein and Acromegaly
Hormone Research in Paediatrics, 2007<i>Background:</i> Recently, researchers at the Oulu University Hospital and the University of Helsinki identified a large pedigree segregating prolactinomas and somatotropinomas. Results suggest that this family from Northern Finland has a possible low penetrance of hereditary predisposition to development of pituitary adenoma, and in ...
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