Results 81 to 90 of about 1,542,659 (289)

Dioxin/Aryl Hydrocarbon Receptor network diagram

, 2022
Adverse outcome pathway network generated by merging AOPs involving the aryl hydrocarbon receptor, with network communities labeled in red. Communities roughly correspond to the following adverse outcomes: (A.) Liver steatosis, (B.) impaired fertility ...
Joseph Romano (434430)
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

aip Mutant Zebrafish Display Morphological and Transcriptional Changes Associated with Stress-Induced Hematopoiesis

Toxics
The Aryl Hydrocarbon Receptor (AHR) is a versatile receptor that binds various compounds, triggering downstream transcriptional changes involved in the regulation of xenobiotic metabolism and cell fate.
Spencer R. Stinson, Jane K. La Du, Dante M. Perone, Sibel I. Karchner, Neelakanteswar Aluru, Lisa Truong, Mark E. Hahn, Robyn L. Tanguay   +7 more
doaj   +1 more source

The aryl hydrocarbon receptor: a predominant mediator for the toxicity of emerging dioxin-like compounds

Journal of Hazardous Materials, 2021
The aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) family of transcription factors and has broad biological functions.
Wanglong Zhang, H. Q. Xie, Yunping Li, Mingxi Zhou, Zhiguang Zhou, Renjun Wang, M. Hahn, Bin Zhao   +7 more
semanticscholar   +1 more source

Covalent Functionalization of 2D Semiconductors: A Roadmap to Advanced Electronic Devices

Advanced Functional Materials, EarlyView.
This Review presents recent advances in the covalent functionalization strategies for two‐dimensional semiconductors and their implementation in modern technologies. Layered materials are modified through diverse molecular chemistries (e.g., thiols, diazonium salts, alkyl halides, and electron‐deficient species) to tailor their surface properties ...
Ramiro Quirós‐Ovies, Bin Han, Paolo Samorì   +2 more
wiley   +1 more source

Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor

bioRxiv, 2020
The epidermis forms a barrier that defends the body from desiccation and entry of harmful substances, while sensing and integrating environmental signals. The tightly orchestrated cellular changes required for the proper formation and maintenance of this
A. Uberoi, C. Bartow-Mckenney, Qi Zheng, L. Flowers, A. Campbell, S. Knight, Neal Chan, Monica Wei, V. Lovins, J. Bugayev, Joseph Horwinski, Charles W. Bradley, Jason M. Meyer, D. Crumrine, C. H. Sutter, P. Elias, E. Mauldin, T. Sutter, E. Grice   +18 more
semanticscholar   +1 more source

Phenobarbital induces cytochrome P4501A2 hnRNA, mRNA and protein in the liver of C57BL/6J wild type and aryl hydrocarbon receptor knock-out mice [PDF]

, 1998
The aryl hydrocarbon receptor mediates the transcriptional response to a variety of hydrocarbons of members of the aryl hydrocarbon gene battery. Phenobarbital does not bind the aryl hydrocarbon receptor with high affinity but induces, in liver cells ...
Marc, Nathalie, André Guillouzo, Thierry Pineau, Laurent Corcos, Pineau, Thierry, Alain Fautrel, Wein, Sharon, Nathalie Marc, Sharon Wein, Fautrel, Alain, Corcos, Laurent, Guillouzo, André   +11 more
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

1,2‐Bis(boronate) Arenes by Borylation Directed Borylation

Angewandte Chemie, EarlyView.
Boron electrophiles derived from tetrabromo‐pyrazaboles and AlCl3 affect the regioselective vicinal double C–H borylation of a range of arenes and polycyclic aromatic hydrocarbons (PAHs). A subsequent pinacol installation step then affords the vicinal bis‐boronate ester‐substituted arene/PAH.
Anna V. Schellbach, Mathew J. Cross, Emily Noone, Cate S. Anstöter, Michael J. Ingleson   +4 more
wiley   +2 more sources

AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

Nature Communications, 2017
In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.
Bojun Chen, Ping Liu, Edward J. Hujber, Yan Li, Erik M. Jorgensen, Zhao-Wen Wang   +5 more
doaj   +1 more source