Results 61 to 70 of about 1,542,659 (289)

Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β

BMC Pharmacology and Toxicology, 2022
Background The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs.
Mengdi Zhang, Yuxia Hu, Fan Yang, Jingwen Zhang, Jianxin Zhang, Wanjia Yu, Minjie Wang, Xiaoli Lv, Jun Li, Tuya Bai, Fuhou Chang   +10 more
doaj   +1 more source

Aryl hydrocarbon receptor: current perspectives on key signaling partners and immunoregulatory role in inflammatory diseases

Frontiers in Immunology
The aryl hydrocarbon receptor (AhR) is a versatile environmental sensor and transcription factor found throughout the body, responding to a wide range of small molecules originating from the environment, our diets, host microbiomes, and internal ...
F. Bahman, Khubaib Choudhry, Fatema Al-Rashed, F. Al-Mulla, S. Sindhu, Rasheed Ahmad   +5 more
semanticscholar   +1 more source

Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4

, 2017
The aryl hydrocarbon receptor (AhR) is a ligand-dependent-activated transcriptional factor that regulates the metabolism of xenobiotic and endogenous compounds.
Lee, Chen-Chen;Yang, Wen-Hao;Li, Ching-Hao;Cheng, Yu-Wen;Tsai, Chi-Hao;Kang, Jaw-Jou, 康照洲   +1 more
core   +1 more source

Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [PDF]

, 2009
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on reproductive or endocrine functions, female Sprague-Dawley rats were
Chen, Xi, Chun-mei Zhang, Jing Liu, Ma, X.M., Zhang, C.M., Zhao, L.J., Zhang, Chun-mei, Chen, X., Li-jun Zhao, Sun, M., Ma, Xiao-ming, Coenraads, P.J., Tang, N.J., Liu, J., Tang, Nai-jun, Liu, Jing, Zhao, Li-jun, Xi Chen, Pieter-Jan Coenraads, Ma, S.W., Shi-wei Ma, Min Sun, Coenraads, Pieter-Jan, Xiao-ming Ma, Sun, Min, Ma, Shi-wei, Nai-jun Tang   +26 more
core   +2 more sources

Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR) [PDF]

Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast.

core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Aryl hydrocarbon receptor controls regulatory CD4+T cell function

Swiss Medical Weekly, 2012
The ligand activated transcription factor aryl hydrocarbon receptor (AhR) has been studied for many decades in toxicology as the ligand for the environmental contaminant dioxin. However, AhR has recently emerged as a critical physiological regulator
Caroline Pot
doaj   +1 more source

The Aryl Hydrocarbon Receptor: Impact on the Tumor Immune Microenvironment and Modulation as a Potential Therapy

Cancers
Simple Summary The aryl hydrocarbon receptor (AhR) is a cytoplasmic and environmental receptor that responds to both exogenous and endogenous ligands to impart a broad range of functions and thereby significantly impact cancer progression. AhR activation
Brian D. Griffith, Timothy L. Frankel
semanticscholar   +1 more source

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The gut microbiome comprises trillions of microorganisms that inhabit the mammalian intestines. These microbes regulate many aspects of host physiology, including defense mechanisms against factors that contribute to inflammatory bowel ...
Samantha A. Scott, Jingjing Fu, Pamela V. Chang   +2 more
semanticscholar   +1 more source

Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor.

Annual Review of Pharmacology and Toxicology, 2021
The aryl hydrocarbon receptor (AhR) is a transcriptional factor that regulates multiple functions following its activation by a variety of ligands, including xenobiotics, natural products, microbiome metabolites, and endogenous molecules. Because of this
Lucie Larigot, Louise Benoit, M. Koual, C. Tomkiewicz, R. Barouki, X. Coumoul   +5 more
semanticscholar   +1 more source