Results 91 to 100 of about 7,533 (241)

The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome

PROTEOMICS, Volume 25, Issue 7, April 2025.
ABSTRACT Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states. Here, we employed coronary artery perfusion with membrane‐impermeant biotin to label and capture the surface‐accessible proteome in the neo ...
Iasmin Inocencio, Alin Rai, Daniel Donner, David W. Greening   +3 more
wiley   +1 more source

Investigation of the Molecular Mechanisms of Paraoxonase‐2 Mediated Radiotherapy and Chemotherapy Resistance in Oral Squamous Cell Carcinoma

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a common form of cancer, with 390,000 new cases estimated for 2022. OSCC has a poor prognosis, largely due to a high recurrence rate and resistance to therapy. Cancer cells develop resistance to standard therapy owing to various factors, such as genetic predispositions, alterations in the apoptotic ...
Mehta Vedant Kamal, Krishnananda Prabhu, Krishna Sharan, Ananth Pai, Sanjiban Chakrabarty, Rama Rao Damerla, Preethi S. Shetty, Vijetha Shenoy Belle, Mahadev Rao, Naveena A. N. Kumar   +9 more
wiley   +1 more source

Oxidative stress products in type 2 diabetes and their relation to paraoxonase 1 activity [PDF]

, 2011
The present study indicated a significant increase in the serum advanced oxidn. protein products (AOPP) and malondialdehyde (MDA) a marker of lipid peroxidn., in diabetic group compared to control group. AOPP was found to be pos. correlated with MDA and
Ahmed Qahtan, ., Ali Abdulqaw, ., Manjunath, N.H.   +2 more
core  

Connection between oral health and chronic diseases

MedComm, Volume 6, Issue 1, January 2025.
Mechanisms linking oral health to chronic diseases. The figure highlights oral health connections to diabetes, cardiovascular diseases, rheumatoid arthritis, and respiratory diseases. Key mechanisms include inflammation, microbial dysbiosis, oxidative stress, and immune dysregulation, emphasizing the systemic impacts of oral diseases like periodontitis.
Di Fu, Xingyue Shu, Ge Zhou, Mengzhen Ji, Ga Liao, Ling Zou   +5 more
wiley   +1 more source

Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat

Journal of Lipid Research, 2009
Paraoxonases (PONs) are a small family of antioxidant enzymes whose antiatherogenic activity is well known. The aim of the present study was the evaluation of the effects of moderate aerobic training on their expression using a rat model.
Rita Romani, Gianna Evelina De Medio, Simona di Tullio, Rosa Lapalombella, Irene Pirisinu, Vittoria Margonato, Arsenio Veicsteinas, Marina Marini, Gabriella Rosi   +8 more
doaj   +1 more source

Attenuating Potential of Ginger (Zingiber officinale) Against Fluoride and Dimethoate‐Induced Oxidative Stress–Associated Hepatotoxicity in Wistar Rats

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
The chronic intake of fluoride (F)‐contaminated groundwater, clinically manifested as fluorosis, is a significant disease burden worldwide. Similarly, dimethoate (DM), a broad‐spectrum organophosphorus insecticide, is one of the most indiscriminately used insecticides in many parts of the world, posing health risks to exposed humans and animals. In the
Priyanka Sharma, Pawan Kumar Verma, Shilpa Sood, Sheen Tukra, Bhawani Singh, Gholamreza Abdi, Zuhaib F. Bhat, Nizar Tlili   +7 more
wiley   +1 more source

Effect of lipoic acid on paraoxonase-1 and paraoxonase-3 protein levels, mRNA expression and arylesterase activity in liver hepatoma cells.

General Physiology and Biophysics, 2017
Paraoxonase-1 (PON1) and PON3 (PON3) are anti-atherosclerotic enzymes, synthesized primarily in liver and bound to HDL in circulation. The aim of the present study was to investigate the effects of therapeutic doses of lipoic acid on PON1 and PON3 ...
E. Ozgun, Gulben Sayilan Ozgun, Kıymet Tabakçıoğlu, Selma Suer Gokmen, N. Sut, S. Eskiocak   +5 more
semanticscholar   +1 more source

Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease [PDF]

, 2009
Background Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates the production of the pro-inflammatory monocyte chemoattractant protein-1 (MCP-1).
Judit Marsillach, Jordi Camps, Natàlia Ferré, Raul Beltran, Anna Rull, Bharti Mackness, Michael Mackness, Jorge Joven, M Parola, I Leviev, L Rodrigo, BN La Du, N Ferré, N Ferré, J Marsillach, C Zhang, B Ustundag, KJ Simpson, C Daly, MJ Czaja, J Marsillach, B Coll, JP Iredale, MJ Arthur, W Jiménez, N Ferré, M Gassó, O Khersonsky, L Gaidukov, J Marsillach, AB Goulter, H Chung, R Bataller, KK Kharbanda, K Hensley, M Parola, E Zamara, M Czaja, F Marra, T Tabata, F Marra, E Zamara, M Parola, B Mackness, M Navab, C Fürnsinn, Y Fan, M Pesant, M Cabré, XP Yang, M Karin, M Aviram, M Aviram, B Li   +53 more
core   +2 more sources

Clinical glycoproteomics: methods and diseases

MedComm, Volume 5, Issue 10, October 2024.
An overview of clinical glycoproteomics: methods and diseases. The primary types of glycosylations include N‐glycosylation and O‐glycosylation. Three main glycoproteomic strategies are employed, with the bottom‐up approach being the most commonly utilized.
Yujia Wang, Kaixin Lei, Lijun Zhao, Yong Zhang   +3 more
wiley   +1 more source

EFFECT OF CARBON TETRACHLORIDE UPON ARYLESTERASES IN MICE

Japanese Journal of Pharmacology, 1970
Early works by Augustinsson (1-4) demonstrated that three types of esterases exist in vertebrate plasma in regard to substrate specificity and susceptibility to selective inhibitors, and he classified them into arylesterases [EC 3. 1. 1. 2], aliesterases (carboxylesterases) [EC 3.1.1.1] and cholinesterases [EC 3.1.1.8].
N, Takahashi, M, Nakazawa, T, Watanabe
openaire   +3 more sources