Results 41 to 50 of about 13,826 (249)
\u3cem\u3eArabidopsis thaliana\u3c/em\u3e GLX2-1 Contains a Dinuclear Metal Binding Site, but Is Not a Glyoxalase 2 [PDF]
, 2009 In an effort to probe the structure and function of a predicted mitochondrial glyoxalase 2, GLX2-1, from Arabidopsis thaliana, GLX2-1 was cloned, overexpressed, purified and characterized using metal analyses, kinetics, and UV–visible, EPR, and 1H-NMR ...
Bennett, Brian +3 more
core +2 more sources
METACHROMATIC LEUKODYSTROPHY WITHOUT ARYLSULFATASE A DEFICIENCY [PDF]
Pediatric Research, 1979 Two siblings of consanguinous parents were noted to have a neurologic syndrome marked by developmental delay, regression of psychomotor performance, marked spasticity and progressive central nervous system degeneration. Markedly delayed nerve conduction times and a sural nerve biopsy which demonstrated changes typical of metachromatic leukodystrophy ...
L J, Shapiro +8 more
openaire +2 more sources
Acta Scientiarum: Biological Sciences, 2023 Soil microbiota has a key role in the dynamics of natural and agro-ecosystems and is sensitive to changes in these environments. This study evaluated changes in the microbiological properties of soils under an organic production system of banana ‘BRS ...
Luana Silva Cerqueira +3 more
doaj +1 more source
Long-term cognitive follow-up in children treated for Maroteaux-Lamy syndrome [PDF]
, 2015 Background: It remains unclear to what extent the brain is affected by Maroteaux-Lamy syndrome (MPS VI), a progressive lysosomal storage disorder. While enzyme replacement therapy (ERT) elicits positive effects, the drug cannot cross the blood–brain ...
Aarsen, F.K. (Femke) +8 more
core +1 more source
Arylsulfatase K, a Novel Lysosomal Sulfatase [PDF]
Journal of Biological Chemistry, 2013 The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation.
Wiegmann, Elena +5 more
openaire +2 more sources
Drug Testing and Analysis, EarlyView.Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg +6 more
wiley +1 more source
Annals of Clinical and Translational Neurology, 2023 Objective Metachromatic leukodystrophy is a lysosomal storage disease caused by deficient arylsulfatase A. It is characterized by progressive demyelination and thus mainly affects the white matter.
Murtadha Al‐Saady +13 more
doaj +1 more source
Insights on cytotoxic cells of the colonial ascidian Botryllus schlosseri [PDF]
, 2015 Morula cells (MCs) represent the most abundant circulating hemocyte of the compound ascidian Botryllus schlosseri. They are cytotoxic cells involved in the rejection reaction between contacting, genetically incompatible colonies.
Ballarin, Loriano +2 more
core
Journal of Applied Toxicology, EarlyView.ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui +2 more
wiley +1 more source
Учёные записки Казанского университета: Серия Естественные наукиLysosomal storage diseases are a group of inherited disorders caused by lysosomal dysfunction, impairing cellular metabolic enzymes, signaling pathways, and other biological processes.
A. I. Mullagulova +5 more
doaj +1 more source