Results 41 to 50 of about 14,004 (249)
Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia. [PDF]
PLoS ONE, 2012 This report presents evidence of 1) a role for arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) in mediating intracellular oxygen signaling; 2) replication between the effects of ARSB silencing and hypoxia on sulfated glycosaminoglycan content ...
Sumit Bhattacharyya, Joanne K Tobacman
doaj +1 more source
Long-term cognitive follow-up in children treated for Maroteaux-Lamy syndrome [PDF]
, 2015 Background: It remains unclear to what extent the brain is affected by Maroteaux-Lamy syndrome (MPS VI), a progressive lysosomal storage disorder. While enzyme replacement therapy (ERT) elicits positive effects, the drug cannot cross the blood–brain ...
Aarsen, F.K. (Femke) +8 more
core +1 more source
Microbiological characterization of land set-aside before and after Roundup desiccation
Plant, Soil and Environment, 2011 Luvic chernozem (set-aside from 1996) was evaluated. The first period, before Roundup desiccation (2002-2003), was characterized by black, spontaneous and controlled fallows (mowed with the removal of plant biomass or mulched); the following period (2003-
M. Růžková +4 more
doaj +1 more source
Lead toxicity and genetics in Flint, MI [PDF]
, 2018 It has been well established that lead poisoning, as defined by the CDC as blood lead levels (BLLs) at or above 5 μg/dl, can lead to long-term neurotoxic effects in children and requires immediate treatment.
Housman, David E +2 more
core +1 more source
METACHROMATIC LEUKODYSTROPHY WITHOUT ARYLSULFATASE A DEFICIENCY [PDF]
Pediatric Research, 1979 Two siblings of consanguinous parents were noted to have a neurologic syndrome marked by developmental delay, regression of psychomotor performance, marked spasticity and progressive central nervous system degeneration. Markedly delayed nerve conduction times and a sural nerve biopsy which demonstrated changes typical of metachromatic leukodystrophy ...
L J, Shapiro +8 more
openaire +2 more sources
Acta Scientiarum: Biological Sciences, 2023 Soil microbiota has a key role in the dynamics of natural and agro-ecosystems and is sensitive to changes in these environments. This study evaluated changes in the microbiological properties of soils under an organic production system of banana ‘BRS ...
Luana Silva Cerqueira +3 more
doaj +1 more source
気管支喘息の臨床分類とその細胞性および液性因子の特徴 [PDF]
, 1993 Characteristics of each asthma type classified by clinical symptoms and findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients ...
Hiramatsu, Junichi +11 more
core +1 more source
Arylsulfatase K, a Novel Lysosomal Sulfatase [PDF]
Journal of Biological Chemistry, 2013 The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation.
Wiegmann, Elena +5 more
openaire +2 more sources
iMetaOmics, EarlyView.First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, 2023 Objective Metachromatic leukodystrophy is a lysosomal storage disease caused by deficient arylsulfatase A. It is characterized by progressive demyelination and thus mainly affects the white matter.
Murtadha Al‐Saady +13 more
doaj +1 more source