Results 31 to 40 of about 25,056,579 (316)

In vitro metabolic studies of REV-ERB agonists SR9009 and SR9011 [PDF]

, 2016
SR9009 and SR9011 are attractive as performance-enhancing substances due to their REV-ERB agonist effects and thus circadian rhythm modulation activity.
Deventer, Koen, Geldof, Lore, Roels, Kris, Tudela Palomar, Eva, Van Eenoo, Peter   +4 more
core   +3 more sources

Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A‐deficient immortalized mesenchymal stromal cells

Human Mutation, 2017
Metachromatic leukodystrophy (MLD) is an autosomal‐recessive lysosomal storage disease caused by mutations in the ARSA gene leading to arylsulfatase A (ARSA) deficiency and causing sulfatide accumulation.
J. Böhringer, R. Santer, N. Schumacher, Friederike Gieseke, K. Cornils, M. Pechan, B. Kustermann-Kuhn, R. Handgretinger, L. Schöls, K. Harzer, I. Krägeloh-Mann, I. Müller   +11 more
semanticscholar   +1 more source

Microbiological properties of soils are sensitive to changes provided by organic cultivation of banana ‘BRS Princesa’ in the semi-arid region

Acta Scientiarum: Biological Sciences, 2023
Soil microbiota has a key role in the dynamics of natural and agro-ecosystems and is sensitive to changes in these environments. This study evaluated changes in the microbiological properties of soils under an organic production system of banana ‘BRS ...
Luana Silva Cerqueira, Aldo Vilar Trindade, Luciano Ricardo Braga Pinheiro, Carla da Silva Sousa   +3 more
doaj   +1 more source

Long-Term Consequences of Increased Activity of Urine Enzymes After Cardiac Surgery – A Prospective Observational Study

Therapeutics and Clinical Risk Management, 2022
Jowita Biernawska,1 Katarzyna Kotfis,2 Jolanta Szymańska-Pasternak,3 Anna Bogacka,4 Joanna Bober3 1Department of Anesthesiology and Intensive Therapy, Pomeranian Medical University, Szczecin, Poland; 2Department of Anesthesiology, Intensive ...
Biernawska J, Kotfis K, Szymańska-Pasternak J, Bogacka A, Bober J   +4 more
doaj  

Brain MRI and biological diagnosis in five Tunisians MLD patients

Diagnostic Pathology, 2012
Metachromatic leukodystrophy (MLD) is a recessive autosomal disease which is characterized by an accumulation of sulfatides in the central and peripheral nervous system. It is due to the enzyme deficiency of the sulfatide sulfatase i.e.
Barboura Ilhem, Hadded Samir, Chebel Saber, Mansour Rachida, Chahed Hinda, Gueddiche Mohamed-Néji, Frih-Ayed Mahbouba, Ferchichi Salima, Miled Abdelhédi   +8 more
doaj   +1 more source

Measurement of sulfatides in the amniotic fluid supernatant: A useful tool in the prenatal diagnosis of metachromatic leukodystrophy

JIMD Reports, 2022
Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal disorder caused by deficiency of arylsulfatase A (ARSA), leading to an accumulation of sulfatides.
Francyne Kubaski, Zackary M. Herbst, Maira Graeff Burin, Kristiane Michelin‐Tirelli, Franciele B. Trapp, Rejane Gus, Alice B. O. Netto, Ana Carolina Brusius‐Facchin, Sandra Leistner‐Segal, Maria Teresa Sanseverino, Carolina Moura Fischinger de Souza, Matheus V. M. B. Wilke, Thiago Oliveira, Jose A. A. Magalhães, Roberto Giugliani   +14 more
doaj   +1 more source

Soil enzymatic activity under coffee cultivation with different water regimes associated to liming and intercropped brachiaria

Ciência Rural, 2021
: This research evaluated the effects of coffee cultivation with two different water regimes associated or not with liming and the presence/absence of brachiaria as intercrop on the activities of the soil enzymes β-glucosidase, arylsulfatase and acid ...
Raquel Nogueira Rodrigues, Fábio Bueno dos Reis Junior, André Alves de Castro Lopes, Omar Cruz Rocha, Antônio Fernando Guerra, Adriano Delly Veiga, Ieda de Carvalho Mendes   +6 more
doaj   +1 more source

Shapes and Positions of Black Hole Shadows in Accretion Disks and Spin Parameters of Black Holes [PDF]

J.Korean Phys.Soc.45:S1808-S1812,2004; Astrophys.J.611:996-1004,2004, 2004
Can we determine a spin parameter of a black hole by observation of a black hole shadow in an accretion disk? In order to answer this question, we make a qualitative analysis and a quantitative analysis of a shape and a position of a black hole shadow casted by a rotating black hole on an optically thick accretion disk and its dependence on an angular ...
arxiv   +1 more source

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy.

Molecular Therapy, 2015
Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder resulting from a functional deficiency of arylsulfatase A (ARSA), an enzyme that catalyzes desulfation of 3-O-sulfogalactosylceramide (sulfatide).
Jonas Doerr, Annika Böckenhoff, B. Ewald, J. Ladewig, M. Eckhardt, V. Gieselmann, U. Matzner, O. Brüstle, P. Koch   +8 more
semanticscholar   +1 more source

Identification of a novel mutation in ARSA gene in three patients of an Iranian family with metachromatic leukodystrophy disorder

Genetics and Molecular Biology, 2017
Metachromatic leukodystrophy disorder (MLD) is an autosomal recessive and lysosomal storage disease. The disease is caused by the deficiency of the enzyme arylsulfatase A (ARSA) which is encoded by the ARSA gene. Different mutations have been reported in
Neda Golchin, Mohammadreza Hajjari, Reza Azizi Malamiri, Majid Aminzadeh, Javad Mohammadi-asl   +4 more
doaj   +1 more source