Results 41 to 50 of about 113,935,104 (175)

Enzymatic Activity in Different Crop Succession Systems in the Cerrado Region

Agronomy
The enzymatic activity of soil arylsulfatase and β-glucosidase enzymes are biological parameters used to measure the biological activity of soils, an important tool for identifying disturbances in agricultural systems, as they are more sensitive to ...
Vanessa Brenda Souza Chaves, Tiara Moraes Guimarães, Aracy Camilla Tardin Pinheiro Bezerra, Claudio Hideo Martins da Costa, Simério Carlos Silva Cruz   +4 more
doaj   +1 more source

Comprehensive clinical, biochemical, radiological and genetic analysis of 28 Turkish cases with suspected metachromatic leukodystrophy and their relatives

Molecular Genetics and Metabolism Reports, 2020
Metachromatic leukodystrophy (MLD) is a glycosphingolipid storage disease caused by deficiency of the lysosomal enzyme arylsulfatase A (ASA) or its activator protein saposin B. MLD can affect all age groups in severity varying from a severe fatal form to
Faruk Pekgül, Nesibe Gevher Eroğlu-Ertuğrul, Can Ebru Bekircan-Kurt, Sevim Erdem-Ozdamar, Arda Çetinkaya, Ersin Tan, Bahadır Konuşkan, Ergun Karaağaoğlu, Meral Topçu, Nurten Ayşe Akarsu, Kader K. Oguz, Banu Anlar, Hatice Asuman Özkara   +12 more
doaj   +1 more source

Nonclinical comparability studies of recombinant human arylsulfatase A addressing manufacturing process changes. [PDF]

PLoS ONE, 2018
Recombinant human arylsulfatase A (rhASA) is in clinical development for the treatment of patients with metachromatic leukodystrophy (MLD). Manufacturing process changes were introduced to improve robustness and efficiency, resulting in higher levels of ...
Teresa Wright, Aiqun Li, Jason Lotterhand, Anne-Renee Graham, Yan Huang, Nancy Avila, Jing Pan   +6 more
doaj   +1 more source

Wilson's disease with Leu492Ser mutation and arylsulfatase A pseudodeficiency: just a coincidence?

, 2004
Wilson's disease (WD) is an autosomal recessive disorder of copper transport, related to mutations of the ATP7B gene (McKusick 277900). Here we report a new case of WD in which a rare mutation, Leu492Ser expressed for the first time in homozygosity, is ...
BATTISTI C., AMATO T., DOTTI M. T., FEDERICO A., BATTISTINI S., DESSÌ V., LOUDIANOS G., RUFA A.   +7 more
core   +1 more source

Ocular Manifestation in a Rare Case of Mucopolysaccharidosis VI

Journal of Mazandaran University of Medical Sciences, 2021
Mucopolysaccharidosis VI is an inherited autosomal recessive disease that causes glycosaminoglycan deposition in different tissues due to arylsulfatase deficiency that can cause various systemic and ocular manifestations.
Leila Rezaei, Naser Aghaei
doaj  

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Identification of neurodegeneration indicators and disease progression in metachromatic leukodystrophy using quantitative NMR‐based urinary metabolomics

JIMD Reports, 2022
Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a deficiency of the arylsulfatase A (ARSA). ARSA deficiency leads to an accumulation of sulfatides primarily in the nervous system ultimately causing demyelination. With evolving
Lucia Laugwitz, Laimdota Zizmare, Vidiyaah Santhanakumaran, Claire Cannet, Judith Böhringer, Jürgen G. Okun, Manfred Spraul, Ingeborg Krägeloh‐Mann, Samuel Groeschel, Christoph Trautwein   +9 more
doaj   +1 more source

Organic Matter Quality and Microbial Activity in Soils Managed With Brachiaria Succession

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Background Although succession systems and brachiaria improve soil quality, gaps remain in microbial community dynamics, activity, and soil organic matter stocks. Methods The objective was to evaluate the carbon (C) and nitrogen (N) stocks of soil organic matter fractions and their distribution, molecular characterization, enzyme activity ...
Siro Paulo Moreira, Vanessa Maria de Souza Barros, David Gabriel Campos Pereira, Humberto Josué de Oliveira Ramos, Eric Batista Ferreira, Teogenes Senna de Oliveira   +5 more
wiley   +1 more source

A new arylsulfatase from the marine mollusk Turbo chrysostomus

, 2012
International audienceA new arylsulfatase (EC 3.1.6.1) was isolated from the liver of the marine mollusk Turbo chrysostomus. The enzyme catalyzed hydrolysis of potassium p-nitrophenylsulfate, did not affect natural fucoidan, and catalyzed cleavage of ...
Sil'Chenko, Ar S., Haertlé, Thomas, Sil'Chenko, Al S., Kicha, A. A., Sova, V. V., Pesentseva, M. S., Zvyagintseva, T. N.   +6 more
core   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source