Results 51 to 60 of about 6,281 (181)
Clinical Genetics, Volume 110, Issue 1, Page 125-130, July 2026.We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig +5 more
wiley +1 more source
Accumulation of lysosulfatide in the brain of arylsulfatase A-deficient mice
Lipids in Health and Disease, 2011 Lysosomal storage diseases are a group of disorders where accumulation of catabolites is manifested in the lysosomes of different cell types. In metachromatic leukodystrophy (Arylsulfatase A [EC.3.1.6.8] deficiency) storage of the glycosphingolipid ...
Månsson Jan-Eric +2 more
doaj +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Arylsulfatase G, a Novel Lysosomal Sulfatase [PDF]
Journal of Biological Chemistry, 2008 The sulfatases constitute a conserved family of enzymes that specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. By modifying the sulfation state of their substrates, sulfatases play a key role in the control of physiological processes, including cellular degradation, cell ...
Frese, Marc-Andre +2 more
openaire +4 more sources
Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction [PDF]
BioImpacts, 2019 Introduction: Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease, is a diverse clinical entity that occurs after podocyte injury.
Shiva Kalantari +5 more
doaj +1 more source
Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.The study shows that Bacillus firmus‐based bionematicides modulate soil microbiota and enhance soybean growth in the Pampa biome. Effects vary by location and time, with increased beneficial bacteria, reduced fungi, and decreased root nematode infestation. Overall, B.
David Fagundes +4 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 5, Page 669-677, May 2026.Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg +6 more
wiley +1 more source
CO 2 Fluxes and Soil Responses to Straw and Herbicide in Peanut
Land Degradation &Development, Volume 37, Issue 7, Page 2927-2944, 30 April 2026.ABSTRACT Peanut cultivation plays an important agronomic role in Brazil, especially in rotation with sugarcane, promoting biological nitrogen fixation and improving soil quality. This study aimed to test the hypothesis that the combined use of sugarcane mulch, peanut cultivation, and herbicide application would affect soil CO₂ fluxes, soil chemical ...
Heytor Lemos Martins +7 more
wiley +1 more source
Agrosystems, Geosciences &Environment, Volume 9, Issue 1, March 2026.Abstract Enzyme activity studies provide an indicator of soil health related to soil management practices. As land area seeded to corn (Zea mays L.) and corn yields increase in this region, demands for plant nutrients also increase to support the high yields.
Almagul Malimbayeva +4 more
wiley +1 more source