Results 61 to 70 of about 113,935,104 (175)

Metachromatic Leukodystrophy: Diagnosis, Modeling, and Treatment Approaches

Frontiers in Medicine, 2020
Metachromatic leukodystrophy is a lysosomal storage disease, which is characterized by damage of the myelin sheath that covers most of nerve fibers of the central and peripheral nervous systems.
Alisa A. Shaimardanova, Daria S. Chulpanova, Daria S. Chulpanova, Valeriya V. Solovyeva, Valeriya V. Solovyeva, Aysilu I. Mullagulova, Kristina V. Kitaeva, Cinzia Allegrucci, Albert A. Rizvanov   +8 more
doaj   +1 more source

Leukodystrophy in Tanzania: A Case Study Highlighting Diagnostic Dilemmas and Clinical Implications

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Leukodystrophies are rare inherited neurodegenerative disorders characterized by progressive white matter dysfunction and neurological decline. In low‐resource settings, limited access to advanced neuroimaging, biochemical investigations, and genetic testing often delays diagnosis and complicates differentiation from more common infectious ...
William Nkenguye, Mujaheed Suleman, Jay Lodhia   +2 more
wiley   +1 more source

Arylsulfatase G, a novel lysosomal sulfatase

, 2008
Frese M-A, Schulz S, Dierks T. Arylsulfatase G, a novel lysosomal sulfatase. JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(17):11388-11395.The sulfatases constitute a conserved family of enzymes that specifically hydrolyze sulfate esters in a wide variety of
Dierks, Thomas, Schulz, Stefanie, Frese, Marc-Andre   +2 more
core   +1 more source

Assessment of Gold‐Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3403-3414, October 2026.
ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui, Adrian Florea, Leila Tekaya   +2 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Detection of a rare Wilson disease mutation associated with arylsulfatase A pseudodeficiency

, 1999
We have studied a patient with Wilson disease (WD), belonging to a family segregating late-onset, dominant cerebellar ataxia, Analysis of the WD gene showed that the patient is a compound heterozygote, carrying the 14His1069Gln mutation from the father ...
Sangiorgi, S., Loudianos, G., Federico, A., Pirastu, M., Battisti, C., Dotti, M. T., Dessì, V., Lovicu, M., Rufa, A.   +8 more
core   +1 more source

Soluble arylsulfatases of human brain and some characteristics of the brain-specific arylsulfatase B_m

, 1980
The brain-specific arylsulfatase Bm (aryl-sulfate sulfohydrolase, EC 3.1.6.1) was demonstrable in human and monkey brain. Arylsulfatases A, B and Bm were separated employing DEAE-cellulose chromatography. There was a distinct difference in the proportion
Lakshmi, S., Balasubramanian, A. S.
core   +1 more source

Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction [PDF]

BioImpacts, 2019
Introduction: Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease, is a diverse clinical entity that occurs after podocyte injury.
Shiva Kalantari, Mohammad Naji, Mohsen Nafar, Hootan Yazdani-Kachooei, Nasrin Borumandnia, Mahmoud Parvin   +5 more
doaj   +1 more source

Microfluidic Intracytoplasmic Sperm Injection (MICSI): A Novel Platform for Sperm Isolation, Selection, and Injection Into Oocytes

Andrology, Volume 14, Issue 7, Page 2252-2261, October 2026.
ABSTRACT Background Infertility is a pressing global health concern, affecting one in six couples worldwide. The failure rate for assisted reproductive technologies (ART) cycles remains at approximately 78%, with limited improvements often attributed to a lack of technological innovation.
Mehran Dabiri, Dale Mark Goss, Steven Alexander Vasilescu, Majid Ebrahimi Warkiani   +3 more
wiley   +1 more source

A two‐tier, reference‐informed framework for soil health assessment: Minimum indicator sets and ecologically dynamic thresholds

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Soil health underpins crop productivity and sustainability, but current soil health assessment frameworks struggle to balance global standardization with regional dynamic ecological realism. Indicators vary widely across soils and climates, often leading to one‐size‐fits‐all thresholds that penalize producers in inherently low‐capacity soils ...
Saurav Das, Lithma Kariyawasam Hetti Gamage, Mitchell Stephenson, Umesh Acharya, Aaron Lee M. Daigh, Bijesh Maharjan   +5 more
wiley   +1 more source